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Moumoujus

SODIUM CYCLODEXTRIN SULFATE.

Valuable CAS 37191-69-8 / EMULSION STABILISING, VISCOSITY CONTROLLING

Sodium Cyclodextrin Sulfate is a modified cyclodextrin celebrated for its exceptional ability to form host-guest inclusion complexes. This property allows it to significantly enhance the solubility, stability, and controlled delivery of active ingredients, thereby optimizing their performance in skincare formulations. Beyond its primary role as a delivery system, it also acts as a sophisticated formulation aid, improving product texture and stability.

Summary

Emulsion Stabilizing Viscosity Controlling Active Ingredient Delivery Enhancer Stabilizing Sensitive Ingredients Odor Masking Texture Improvement Absorbent Skin Protection

Science

Mechanism of Action

This ingredient functions by creating stable inclusion complexes, effectively encapsulating poorly soluble active compounds within its molecular structure. This process boosts their solubility, dramatically improving their bioavailability and penetration into the skin. Furthermore, this encapsulation shields active ingredients from degradation caused by environmental factors like light, heat, UV radiation, and oxidation, extending their efficacy through controlled release. In formulations, Sodium Cyclodextrin Sulfate serves as an emulsion stabilizer, a viscosity controlling agent, and can mask undesirable odors. It also contributes to a refined sensory experience and offers a protective benefit to the skin by mitigating irritation from other substances.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–5%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information regarding 'dusting' or potential misrepresentation of Sodium Cyclodextrin Sulfate concentrations was found in the provided research data.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

The optimal pH range for general cyclodextrins typically lies between 5 and 8. However, sulfated cyclodextrins, including Sodium Cyclodextrin Sulfate, are susceptible to decomposition in formulations with strong acidic or basic pH values. Specifically, beta-cyclodextrin sulfate sodium salt may encounter solubility challenges and decomposition through ester formation during prolonged storage or when heated above 60°C. Despite these sensitivities, cyclodextrins are widely valued for their ability to enhance the stability of encapsulated active ingredients, safeguarding them from various environmental degradation factors.

Synergies

  • Poorly soluble active ingredients (enhances solubility and skin penetration)
  • Sensitive or unstable active ingredients (improves stability and prolongs efficacy)
  • Potentially irritating active compounds (reduces irritation profile)

Conflicts

  • Strong acidic solutions (promotes decomposition)
  • Strong basic solutions (promotes decomposition)
  • Sustained heating above 60°C (may lead to solubility issues and decomposition for related sulfated beta-cyclodextrin forms)

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
5%
Sensitization risk Low

While the Cosmetic Ingredient Review Expert Panel (CIR) has assessed native cyclodextrins and certain derivatives as safe for cosmetic use, specific CIR status for Sodium Cyclodextrin Sulfate is not explicitly available. Nevertheless, alpha-, beta-, and gamma-cyclodextrins are generally recognized as safe (GRAS) by the U.S. FDA, and sulfated cyclodextrins are classified as non-dangerous substances by GHS and Directive 67/548/EEC. General cyclodextrins are considered safe and non-irritating within typical cosmetic concentrations (0.1% to 5%), with rare occurrences of mild irritation or dryness only at exceptionally high concentrations. This ingredient also demonstrates protective qualities, reducing overall skin irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Sodium Cyclodextrin Sulfate is a valuable ingredient, optimizing the performance of active compounds through enhanced delivery and stability, while simultaneously improving formulation aesthetics and offering gentle, protective benefits across all skin types.

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