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SODIUM CYCLIC LYSOPHOSPHATIDIC ACID.

Valuable / HUMECTANT, SKIN CONDITIONING

Sodium Cyclic Lysophosphatidic Acid (NcPA) is a potent phospholipid that significantly contributes to skin health by boosting hydration and elasticity. It actively stimulates the natural synthesis of hyaluronic acid and fortifies the extracellular matrix, while also enhancing the skin barrier.

Summary

Hydration Booster Elasticity Enhancer Barrier Support Anti-aging Agent ECM Booster

Science

Mechanism of Action

NcPA functions by activating specific cellular pathways to improve skin quality. It upregulates the hyaluronan synthase 2 (HAS2) gene expression via the LPAR1-Gi/o, PI3K, ERK, and CREB signaling pathways in human skin fibroblasts, leading to increased hyaluronic acid and extracellular matrix synthesis. Furthermore, a related phospholipid, Lysophosphatidic Acid (LPA), induces filaggrin (FLG) expression in human keratinocytes through LPAR1 and LPAR5 receptors and the RHO-ROCK-SRF pathway, promoting keratinocyte differentiation and strengthening the skin's barrier function.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–0.1%
Optimal

0.1%

Key findings

  1. 01 A 12-week clinical trial involving a serum with 0.1% NcPA (combined with 0.1% hesperetin), applied twice daily, demonstrated significant improvements in stratum corneum hydration and skin elasticity. Histological evaluations confirmed enhanced hyaluronic acid levels and improved elastic fiber structure. Participants reported an impressive 94.3% overall satisfaction rate, indicating significant anti-aging effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While specific data for Sodium Cyclic Lysophosphatidic Acid is limited, information on related LPA sodium salts indicates solubility in both water (e.g., approximately 8.3 mg/ml in PBS at pH 7.2) and various organic solvents. Aqueous solutions are not recommended for storage beyond one day. For optimal stability, stock solutions should be aliquoted and stored frozen at -80°C for up to 6 months or at -20°C for up to 1 month, protected from moisture and repeated freeze-thaw cycles.

Synergies

  • Hesperetin

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Direct safety assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for Sodium Cyclic Lysophosphatidic Acid are not available. The specific FDA status for this ingredient in cosmetics is also not detailed in current research.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Cyclic Lysophosphatidic Acid is a valuable ingredient, clinically shown to significantly enhance skin hydration, elasticity, and barrier function through its ability to boost hyaluronic acid and filaggrin synthesis.

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