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SODIUM COCOYL HYDROLYZED ROYAL JELLY.

Valuable / CLEANSING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

SODIUM COCOYL HYDROLYZED ROYAL JELLY is a sophisticated derivative of royal jelly, meticulously hydrolyzed to optimize its absorption and bioactivity within the skin. It delivers a comprehensive spectrum of benefits, including potent antioxidant and anti-inflammatory actions, while actively bolstering skin resilience and mitigating environmental stressors.

Summary

Antioxidant Anti-inflammatory Skin Conditioning Collagen Boosting Anti-photoaging Barrier Protection Antimicrobial Chelating

Science

Mechanism of Action

This ingredient functions by inhibiting oxidative damage and bolstering the skin's endogenous antioxidant systems, such as glutathione, catalase, and glutathione peroxidase 4, alongside exhibiting effective iron-chelating properties. It precisely modulates inflammatory cascades by downregulating key mediators like NLRP3, IL-1β, COX2, and iNOS. Furthermore, it supports skin homeostasis, stimulates collagen production, and offers protection against UVB-induced photoaging and general epidermal stress via NQO1 expression upregulation. Its hydrolyzed nature significantly enhances cellular absorption and overall efficacy compared to unhydrolyzed royal jelly protein, with additional mild antimicrobial properties.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–10%
Optimal

N/A

Key findings

  1. 01 Formulations containing royal jelly at concentrations between 0.5% and 1% demonstrated a dose-dependent increase in antioxidant activity, with 1% exhibiting the highest efficacy.
  2. 02 Topical application of a cream with 10% royal jelly effectively reduced levels of the inflammatory mediator TNF-α in UVB-induced rat skin tissue.
  3. 03 Hydrolyzed royal jelly peptide (RJP) inhibited oxidative damage caused by H2O2, reduced lipid peroxidation, enhanced glutathione levels, and boosted the activity of catalase and glutathione peroxidase 4 in human dermal fibroblasts, showcasing excellent iron chelating capacity.
  4. 04 RJP modulated NLRP3 inflammasome-mediated inflammatory responses in human dermal fibroblasts, suppressing the mRNA expressions of NLRP3 and IL-1β, and repressing the expressions of COX2 and iNOS.
  5. 05 Hydrolyzed protein from royal jelly (HR) improved cell tolerance, decreased intracellular reactive oxygen species, and suppressed Interleukin (IL)-1α and IL-8 secretion in HaCaT keratinocytes exposed to sodium lauryl sulfate (SLS).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 4.5
0 7 14

Stability

Royal jelly's active components, particularly 10-HDA, are susceptible to rapid degradation and require low-temperature storage (e.g., 6°C) away from light. Encapsulation techniques, such as cyclodextrins and liposomes, can significantly improve its stability and enhance skin penetration. Major Royal Jelly Proteins (MRJPs) exhibit maximal thermal stability and optimal gelatinous viscosity and adherence within a pH range of 4.0 to 5.0.

Conflicts

  • Individuals with known bee or pollen allergies

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Direct regulatory status for SODIUM COCOYL HYDROLYZED ROYAL JELLY by CIR, SCCS, or FDA is not available. However, 'Royal Jelly Extract' is generally regarded as safe for cosmetic use at typical concentrations of 0.1% to 5%, presenting minimal irritation potential for the majority of users. It holds approval in the EU COSING database for its skin conditioning properties. Given its bee-derived nature, individuals with known sensitivities to bee products or pollen should proceed with caution, and thorough patch testing is strongly recommended prior to use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SODIUM COCOYL HYDROLYZED ROYAL JELLY is a valuable ingredient, leveraging its hydrolyzed form to provide substantial antioxidant and anti-inflammatory benefits, thereby enhancing skin resilience and protection against various environmental and internal stressors.

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