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Moumoujus

SODIUM CHOLESTERYL SULFATE.

Valuable CAS 2864-50-8 / SKIN CONDITIONING

Sodium Cholesteryl Sulfate acts as a biomimetic lipid, significantly reinforcing the skin's natural barrier and enhancing moisture retention. It functions as a critical component in promoting epidermal health and stabilizing complex lipid-based cosmetic formulations.

Summary

skin-conditioning emulsifying stabilizing barrier strengthening moisture retention epidermal differentiation stimulator cell membrane stabilizer exfoliant (controls shedding) pH regulator (stratum corneum)

Science

Mechanism of Action

This ingredient operates as a skin-identical lipid, vital for strengthening the epidermal barrier and improving the skin's moisture-holding capacity. At a cellular level, it stimulates epidermal differentiation by activating the η isoform of protein kinase C (PKC), leading to increased phosphorylation of epidermal structural proteins and enhanced cornified envelope formation. It also transcriptionally regulates proteins crucial for cornified envelope development, such as transglutaminase 1 (TGM1) and involucrin, while inducing filaggrin expression through RORα. Additionally, it contributes to the controlled shedding of old skin cells, stabilizes cell membranes, regulates functional proteins, supports keratinocyte differentiation, and acidifies the stratum corneum via cholesterol sulfate ionization and hydrolysis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Sodium Cholesteryl Sulfate is soluble in water due to its sodium ion, increasing its hydrophilicity, and also forms clear solutions in organic solvents like chloroform-methanol, DMSO, and dimethyl formamide. No specific optimal pH range for stability in cosmetic formulations has been identified. For long-term stability, it should be stored in a dry, cold, airtight container below 25 °C, protected from strong acids, acidic bases, and oxidizing agents. Recommended storage temperatures are 0-8 °C for general use, -20 °C for powder (up to 3 years), and -80 °C for solutions (up to 1 year).

Conflicts

  • acidic bases
  • strong acids
  • oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed Sodium Cholesteryl Sulfate. Similarly, the Scientific Committee on Consumer Safety (SCCS) has not published an opinion. While the FDA regulates manufacturers of Sodium Cholesteryl Sulfate when used as an Active Pharmaceutical Ingredient (API), cosmetic products and their ingredients generally do not require pre-market FDA approval, though it is legally prohibited to market harmful cosmetic products.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Cholesteryl Sulfate is a valuable ingredient demonstrating significant mechanistic potential in fortifying the skin barrier, boosting moisture, and promoting healthy epidermal differentiation for dry and sensitive skin, pending comprehensive formal safety reviews.

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