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SODIUM CHLOROPHYLLIN-ZINC COMPLEX.

Insufficient Data CAS 152695-46-0 / ANTIOXIDANT

Sodium Chlorophyllin-Zinc Complex is a water-soluble, semi-synthetic chlorophyll derivative, uniquely structured with a central zinc atom. This ingredient is primarily valued for its potent antioxidant and anti-inflammatory capabilities, offering comprehensive cellular protection and soothing benefits for the skin. The inclusion of zinc further augments its profile with properties beneficial for sebum regulation and supporting healthy skin recovery.

Summary

antioxidant

Science

Mechanism of Action

Sodium Zinc Chlorophyllin (SZC) acts as a powerful antioxidant by exhibiting superior free radical scavenging activity and reducing power in various *in vitro* assays. This enhanced efficacy is attributed to the central zinc atom, which significantly boosts the electron-donating capacity of the porphyrin system. Beyond its antioxidant role, SZC demonstrates anti-inflammatory potential by suppressing lipopolysaccharide-induced inflammatory responses in macrophage cell lines. This includes inhibiting nitric oxide production and downregulating the expression of inducible nitric oxide synthase, all without exhibiting cytotoxicity. The inherent zinc component also contributes to skin health by aiding in wound healing processes, helping to normalize sebum production, and limiting the proliferation of certain acne-causing bacteria.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Sodium Chlorophyllin-Zinc Complex is commonly 'dusted' or used at sub-efficacious concentrations in formulations for misleading claims. Clinical efficacy data with specific concentrations on human skin are currently lacking.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

The formation of the zinc complex is notably enhanced in a slightly acidic to neutral pH environment, with optimal increases observed between pH 4.0 and 6.0. Zn-chlorophyll samples demonstrate improved stability compared to basic chlorophyll in acidic conditions, specifically at pH 5.5. This ingredient also exhibits high thermal stability within temperatures of 40-60 °C and moderate stability up to 70-90 °C, maintaining integrity over periods of 5 to 60 minutes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Natural chlorophylls are generally not considered toxic, and chlorophyllin itself has a history of over 50 years of clinical use without reported systemic toxic effects. However, it's important to note that topical application of sodium copper chlorophyllin (a related compound) on wounds has been reported to cause mild burning or itching in some individuals. Oral consumption of chlorophyllin may increase skin sensitivity to sunlight. Specific safety assessments (e.g., CIR, SCCS, or FDA status) for 'SODIUM CHLOROPHYLLIN-ZINC COMPLEX' as an active cosmetic ingredient are not currently available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Sodium Chlorophyllin-Zinc Complex shows promising *in vitro* antioxidant and anti-inflammatory benefits, and the zinc component offers additional skin advantages, a lack of direct clinical efficacy studies on human skin warrants a 'insufficient-data' rating for definitive recommendation.

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