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Moumoujus

SODIUM BUTYROYL HYALURONATE.

Insufficient Data CAS 942471-70-7 / HUMECTANT, SKIN CONDITIONING

Sodium Butyroyl Hyaluronate is a novel hyaluronic acid derivative engineered to enhance skin's natural defenses. It acts as a potent radical scavenger, offering superior antioxidant and anti-irritant properties, which contributes to its long-lasting moisturizing benefits.

Summary

humectant skin conditioning antioxidant anti-irritant

Science

Mechanism of Action

This advanced hyaluronic acid derivative functions as an exceptional radical scavenger, actively working to protect and prevent the degradation of the body's native hyaluronan molecules. Its unique structure provides significantly stronger antioxidant and anti-irritant effects compared to standard hyaluronates. Furthermore, its enhanced resistance to enzymatic hydrolysis ensures a prolonged and exceptionally long-lasting moisturizing presence on the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in vitro study on hyaluronic-acid-butyric-ester derivatives, which includes components similar to Sodium Butyroyl Hyaluronate, evaluated their anti-proliferative activity in MCF7 cancer cells. The study indicated a progressive improvement in anti-proliferative effects with a degree of substitution up to 0.20 (corresponding to approximately 1.8-28.4% w/w), with effects diminishing beyond this point. This research focused on a specific cellular mechanism, rather than direct topical skin benefits.
  2. 02 Oral supplementation of standard Sodium Hyaluronate (1.8 MDa) at doses of 60 mg/day and 120 mg/day demonstrated improvements in skin hydration, elasticity, and reductions in transepidermal water loss (TEWL), sebum, and periorbital wrinkle depth in human subjects. The 120 mg/day dose showed more significant enhancements, including increased epidermal thickness and dermal density.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

Sodium Butyroyl Hyaluronate is sensitive to extreme pH levels. To maintain optimal efficacy, formulations should target a pH range of 5.0 to 7.5, as exposure to strong acids or bases can destabilize the ingredient and reduce its effectiveness. Viscosity of related hyaluronates is generally stable between pH 6.5 and 8.0.

Conflicts

  • strong acids
  • strong bases
  • high concentrations of alpha hydroxy acids (AHAs)
  • strong exfoliants

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Sodium Butyroyl Hyaluronate has not been individually reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel. While the CIR has assessed related hyaluronates, such as Hyaluronic Acid and Sodium Hyaluronate, as safe for cosmetic use, this specific derivative lacks an explicit, standalone safety assessment. The FDA UNII record for Sodium Butyroyl Hyaluronate (2P689L1H2J) currently indicates a 'FAILED' status due to an 'incomplete polymer record', signifying a gap in its comprehensive regulatory data.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Sodium Butyroyl Hyaluronate presents a promising mechanism for enhanced moisturizing, antioxidant, and anti-irritant effects; however, direct topical human clinical data on its efficacy and optimal concentration are currently lacking for precise formulation guidance.

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