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SODIUM BUTYROYL/FORMOYL HYALURONATE.

Insufficient Data CAS 100201-66-0 / HUMECTANT

A precision-engineered hyaluronic acid derivative, SODIUM BUTYROYL/FORMOYL HYALURONATE is designed for enhanced skin interaction. It offers long-lasting hydration, robust antioxidant protection, and anti-irritant benefits by leveraging increased lipophilicity and resistance to enzymatic degradation.

Summary

Humectant Skin conditioning Antioxidant Anti-irritant Moisturizing Rejuvenating Revitalizing

Science

Mechanism of Action

Through its unique butyrate residues, SODIUM BUTYROYL/FORMOYL HYALURONATE exhibits increased lipophilicity, fostering superior interaction with the epidermal lipid matrix. This modification leads to sustained moisturizing efficacy, attributed to its heightened resistance against enzymatic hydrolysis. Furthermore, it delivers pronounced antioxidant and anti-irritant effects, collectively revitalizing and rejuvenating the epidermis as a potent humectant and skin conditioning agent.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

This hyaluronic acid derivative demonstrates optimal stability within a pH range of 5.0 to 8.0. Similar to its base molecule, Sodium Hyaluronate, it is susceptible to degradation at temperatures above 25°C (or >60°C), extreme pH values (below 4 or above 10), and exposure to light or oxidative conditions. A key benefit of its creation is the successful elimination of the unpleasant odor typically associated with butyrate.

Conflicts

  • Strong acids
  • Some preservatives (potential, based on pure HA)
  • High temperatures
  • Extreme pH conditions
  • Light
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While structurally related to Hyaluronic Acid and Sodium Hyaluronate, which are reviewed by the CIR Expert Panel as safe up to 7.5% concentration, this specific derivative has not undergone a comprehensive safety assessment by the CIR. Toxicity data for oral, parenteral, dermal, and inhalation routes is currently 'Not determined'. It possesses an FDA UNII, signifying identification recognition but not a direct safety approval for cosmetic use. Notably, the ingredient is claimed to have an anti-irritant effect.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

SODIUM BUTYROYL/FORMOYL HYALURONATE presents as a promising hyaluronic acid derivative with enhanced moisturizing, antioxidant, and anti-irritant properties, but lacks specific clinical studies and comprehensive safety assessments for this particular molecule.

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