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SODIUM BISULFATE.

Valuable CAS 7681-38-1 / BUFFERING

Sodium Bisulfate is primarily utilized in skincare as a highly effective pH adjuster, precisely controlling the acidity of formulations. This inorganic salt is crucial for stabilizing products and optimizing the performance of pH-sensitive active ingredients.

Summary

pH adjuster/buffer

Science

Mechanism of Action

As a dry acid, Sodium Bisulfate functions by efficiently lowering the pH of cosmetic formulations. This mechanism ensures product stability and creates an optimal acidic environment, typically ranging from pH 3.0 to 5.0, which is beneficial for the efficacy of various active ingredients, particularly those targeting concerns like acne.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 While directly applicable to a derivative, Andrographolide Sodium Bisulfate (ASB), not Sodium Bisulfate itself, topical application of ASB (3.6 mg/mouse) significantly suppressed UV-induced skin photoaging in mice. This derivative increased skin collagen content by approximately 53.17% and decreased epidermal thickness by about 41.38%, mitigating UV-induced damage to collagen and elastic fibers through its antioxidant and anti-inflammatory properties.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 5
0 7 14

Stability

Stable under normal conditions, but its aqueous solutions can be corrosive to metals. The anhydrous form is hygroscopic and may decompose upon exposure to moist air or water.

Conflicts

  • strong bases
  • strong oxidizing agents
  • sodium carbonate
  • sodium hypochlorite (chlorine bleach)
  • ammonia cleansers
  • alcohol (decomposes)

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Moderate

The CIR Expert Panel concluded Sodium Bisulfate is safe for cosmetic use when formulated to be non-irritating. The FDA generally recognizes it as safe (GRAS) for use in food, requiring careful consideration of potential risks and safety measures in cosmetics.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Bisulfate is a valuable pH adjuster, essential for maintaining product stability and optimizing the efficacy of acid-sensitive actives. However, due to its high irritancy potential, precise formulation is critical to ensure it is non-irritating in skincare applications. While a derivative showed anti-photoaging benefits in mice, these findings do not directly apply to Sodium Bisulfate itself.

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