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Moumoujus

SISYMBRIUM OFFICINALE EXTRACT.

Insufficient Data CAS 84775-99-5 / SKIN CONDITIONING

Sisymbrium Officinale Extract, derived from Hedge Mustard, is distinguished by its richness in active glucosinolates and isothiocyanates. This botanical extract offers notable antioxidant and antimicrobial properties, positioning it as a promising ingredient for skin conditioning and protective formulations.

Summary

Antioxidant Antimicrobial Skin Conditioning Soothing

Science

Mechanism of Action

This extract functions primarily through its high concentration of glucosinolates and their hydrolytic products, isothiocyanates, particularly allylisothiocyanate. These compounds are known to interact as strong agonists of the transient receptor potential ankyrin 1 (TRPA1) channel, which is involved in somatosensory perception and inflammatory pain pathways, potentially offering a myorelaxant effect against inflammatory agents. The extract is also abundant in polyphenolics and flavonoids, contributing to its robust antioxidant capabilities, and has demonstrated significant antimicrobial properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A study demonstrated strong antimutagenic activity against 2-aminoanthracene in specific bacterial strains (Escherichia coli WP2uvrA and Salmonella typhimurium TA98).
  2. 02 An investigation using a 99% ethanol extract revealed strong antioxidant activity (DPPH inhibition 193.7 ± 3.4) and significant antimicrobial efficacy against E. coli (10 mm inhibition) and Streptococcus (14 mm inhibition). This study also reported approximately 6% anticancer activity against MCF7 breast cancer cells.

Transparency

Dusting Analysis

Not commonly dusted

Data concerning the ingredient's propensity for 'dusting' in cosmetic formulations is not available in the provided research.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 5
0 7 14

Stability

The stability and efficacy of Sisymbrium Officinale Extract are highly sensitive to temperature, pH, and processing. Optimal liberation of active isothiocyanates from their precursor, sinigrin, occurs within a narrow pH range of 4.0-5.0. Below pH 3.7, isothiocyanates can convert into less active cyanates. High temperatures or extensive processing can also degrade the myrosinase enzyme, which is crucial for the conversion of glucosinolates to isothiocyanates, thereby reducing the extract's effectiveness.

Conflicts

  • Fermentation processes (e.g., kombucha-type fermentation) can eliminate active isothiocyanates.
  • Strong acidic conditions (below pH 3.7) promote the formation of cyanates instead of beneficial isothiocyanates.
  • High temperatures or extensive processing that degrades the myrosinase enzyme, essential for activation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments for topical use by major regulatory bodies such as CIR, SCCS, or FDA were identified. General health advisories indicate 'Hedge mustard might also be unsafe' for internal use, but this does not directly address topical application safety, which remains largely uncharacterized in the provided data.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting promising antioxidant, antimicrobial, and potentially soothing properties in preliminary studies, a lack of specific topical clinical efficacy and comprehensive safety data currently renders its overall cosmetic value uncertain.

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