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Moumoujus

SILKWORM SH-OLIGOPEPTIDE-2.

Questionable / SKIN CONDITIONING

SH-Oligopeptide-2, also known as Insulin-like Growth Factor 1 (IGF-1), is a synthetic human peptide engineered to mimic natural growth factors. It functions as a potent signaling molecule, activating cellular pathways to promote skin cell proliferation, collagen synthesis, and extracellular matrix component production. This action aims to enhance skin elasticity, reduce the appearance of fine lines, and support overall skin renewal and resilience.

Summary

Cell-communicating ingredient Wound healing Collagen stimulation Elasticity enhancement Hyaluronic acid biosynthesis Epidermal keratinocyte proliferation Fibroblast proliferation Skin barrier strengthening Fine line and wrinkle reduction Skin tone improvement Skin renewal

Science

Mechanism of Action

SH-Oligopeptide-2 operates as a key cell-communicating ingredient by binding to specific receptors on dermal cells, mirroring the action of Insulin-like Growth Factor 1 (IGF-1). This interaction triggers a cascade of intracellular events, notably activating the AKT pathway, which is crucial for cellular proliferation and tissue repair. The peptide actively stimulates fibroblasts to increase collagen and hyaluronic acid production, simultaneously promoting the growth of epidermal keratinocytes to strengthen the skin barrier. Furthermore, it supports the formation of new microvessels, contributing to the revitalization of aged cellular structures, ultimately fostering improved skin integrity, elasticity, and a smoother complexion.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

SH-Oligopeptide-2 is generally recognized as safe for cosmetic applications by regulatory bodies like the European Cosmetics Directive, with no commonly reported serious adverse effects. However, a crucial consideration is its nature as a growth factor-mimicking peptide; such compounds, including recombinant IGF-1, have been correlated with tumorigenesis and progression, specifically melanoma progression. While the ingredient is generally well-tolerated, individuals with dermatological sensitivities should perform a patch test. It is important to note that a specific safety review by the CIR Expert Panel or SCCS for SH-Oligopeptide-2 has not been conducted.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While mechanistically potent for anti-aging and skin repair, the strong correlation of growth factors like SH-Oligopeptide-2 with tumorigenesis and melanoma progression necessitates caution, especially given its 'not reviewed' CIR status.

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