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SILKWORM RH-OLIGOPEPTIDE-2.

Questionable / SKIN CONDITIONING

SILKWORM RH-OLIGOPEPTIDE-2, also known as Insulin-like Growth Factor 1 (IGF-1), is a signaling molecule essential for cell proliferation and tissue repair. It is valued for its anti-aging and skin-renewing properties, enhancing collagen production and skin elasticity.

Cell-communicating ingredient

Science

This ingredient binds to specific skin cell receptors, stimulating collagen synthesis and boosting epidermal keratinocyte proliferation for optimal skin renewal. It also activates the AKT pathway, aiding in anti-aging, and supports the formation of new blood vessels to revitalize damaged cells.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A study demonstrated that 5 ng/ml offered substantial protection from UVB-induced apoptosis in keratinocyte cells.

Transparency

Not commonly dusted

No data is available to suggest common dusting practices for this ingredient.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Growth factors, including SH-Oligopeptide-2, can destabilize in acidic environments, reducing their efficacy. It is recommended to apply acidic products first and wait a few minutes before layering products containing growth factors.

Conflicts

  • strong acids

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

While generally considered safe, a significant caution exists due to its correlation with tumorigenesis. Some individuals may also experience allergic reactions.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Questionable

Despite promising anti-aging and repairing benefits, the potential correlation with tumorigenesis raises significant safety concerns.


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