Science
Mechanism of Action
Silkworm Frass is observed to exert a depigmentation effect through active components identifiable in its methanol extract. Additionally, a related silkworm larvae by-product (SLPY) has shown anti-inflammatory capabilities by inhibiting critical cellular signaling pathways, specifically targeting NF-κB nuclear translocation and MAPK signaling.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Silkworm droppings extract demonstrated non-toxicity to human fibroblast cells and a dose-dependent depigmentation effect in zebrafish larvae.
- 02 A powdered by-product of mature silkworm larvae (SLPY) exhibited no cell toxicity in HaCaT cells and effectively inhibited inflammatory responses by blocking NF-κB nuclear translocation and MAPK signaling.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Silkworm droppings extract was evaluated for toxicity on human fibroblast cells and zebrafish embryos, demonstrating non-toxic properties at concentrations up to 400 µg/mL. The CIR Expert Panel has reviewed 'Silk Protein Ingredients' but has not specifically reviewed 'Silkworm Frass'. A related ingredient, 'Silkworm Cocoon Extract', was subject to an 'Insufficient Data Announcement' by CIR in 2015.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Silkworm Frass exhibits promising preliminary data for depigmentation and anti-inflammatory effects in vitro and in zebrafish, but specific human clinical data and comprehensive safety assessments for this ingredient are currently insufficient.
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References
Sources