Science
Mechanism of Action
This ingredient operates via multiple pathways to restore skin balance. It significantly reduces inflammation by inhibiting pro-inflammatory cytokines, enzymes such as prostaglandins and cyclooxygenase, and the 5-lipoxygenase (5-LOX) pathway, thereby preventing leukotriene synthesis. Concurrently, it exhibits broad-spectrum antimicrobial action, including against Propionibacterium acnes (with an MIC of 0.039% for Ichthyol® Pale), alongside anti-fungal and anti-seborrheic properties. Its keratoplastic effects help regulate sebum production, refine pores, and normalize cellular growth and desquamation, promoting healing and a clearer complexion.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Demonstrated anti-inflammatory efficacy comparable to 0.5% hydrocortisone in treating UVB erythema and mild to moderate atopic eczema in children.
- 02 Applied daily for 20 weeks, it significantly enhanced the healing of venous leg ulcers, showing a greater reduction in ulcer area compared to a vehicle group.
- 03 Resulted in significant improvement in scaling for dandruff over 16 days, outperforming a control substance.
- 04 Achieved an 'good' or 'very good' efficacy rating in approximately 76% of cases for eliminating skin impurities (pimples) after a six-week treatment period.
- 05 Reduced the average number of visible skin lesions by approximately 80% over an eight-week treatment phase.
Transparency
Dusting Analysis
Clinical evidence consistently demonstrates efficacy across a range of concentrations from 1% to 10% for various skin conditions, positioning Shale Extract as a potent active ingredient. Its recommended cosmetic concentration range (0.5-5%) further indicates it is used at therapeutically relevant levels, not as a negligible 'dusting' ingredient.
The Formula
Formulation
Stability
Stable across a wide pH range. Precipitation may occur when exposed to strong acids.
Synergies
- Salicylic acid (for enhanced reduction of skin lesions)
Conflicts
- strong acids
- alkali carbonates
- alkali hydrates
- alkaloidal salts
Safety
Safety Profile
Sulfonated shale oil (e.g., Ichthyol® Pale) is non-carcinogenic, non-mutagenic, and REACH registered. Considered safe under German Federal Food Law, it exhibits a large safety factor and is generally well-tolerated. Its inclusion in baby products and sensitive skin formulations underscores its favorable safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Shale Extract is a valuable, multi-targeted ingredient with strong clinical evidence for its anti-inflammatory, antimicrobial, and healing properties, effectively addressing a diverse range of skin concerns from acne and eczema to wound care with a high safety profile.
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