Science
Mechanism of Action
This single-chain synthetic human peptide is produced through fermentation, acting as a bio-identical analogue to Macrophage Colony Stimulating Factor 1 (CSF-1). Its core function involves stimulating the proliferation of dermal mesenchymal cells, which are fundamental to the formation of the dermal papillae, a vital structure for robust hair growth. More broadly, peptides in cosmetic applications are understood to signal the body, activating its inherent repair and regeneration mechanisms within the skin.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Efficacy data for SH-POLYPEPTIDE-73 primarily stems from its inclusion in a multi-component formulation (a hair serum), where its individual contribution to the observed results was not isolated. This makes it challenging to ascertain its specific impact and optimal concentration, indicating a risk of being a 'dusted' ingredient where its presence may be noted without clear standalone efficacy evidence.
The Formula
Formulation
Stability
This ingredient is often formulated within a hyaluronic acid base, which may contribute to its stability or enhance its delivery into the skin or scalp.
Safety
Safety Profile
SH-POLYPEPTIDE-73 is listed in the European Union's CosIng database with a 'skin protecting' function, indicating its approval for cosmetic use. While specific Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) assessments for SH-POLYPEPTIDE-73 were not identified, broader CIR safety evaluations for categories like 'Tissue-Derived Proteins and Peptides' generally conclude these ingredients are safe for cosmetic applications. Products containing SH-POLYPEPTIDE-73 are marketed as safe for all skin types and formulated without parabens, formaldehyde, or synthetic dyes, suggesting a favorable safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-POLYPEPTIDE-73 offers a promising bio-identical mechanism for stimulating dermal cell proliferation, primarily noted for its relevance in hair growth, and is listed for skin protection. However, for precision skincare, dedicated clinical studies isolating its direct efficacy and optimal concentration for skin benefits are currently insufficient.
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References
Sources