Science
Mechanism of Action
This peptide, also identified as sh-Polypeptide-9 or Vascular Endothelial Growth Factor (VEGF), interacts with specific receptors on endothelial cells. This interaction initiates a cascade that stimulates cell proliferation and new blood vessel formation (angiogenesis). The enhanced microcirculation improves oxygen and nutrient supply to the dermal layers, supporting cellular functions, refining skin tone, and improving texture. Additionally, it contributes to skin hydration, provides conditioning, and is suggested to stimulate collagen production, potentially improving skin elasticity and mitigating the appearance of fine lines and wrinkles.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Maintaining the activity of SH-Oligopeptide-9 in cosmetic formulations presents a significant challenge. While stable at extremely cold temperatures (-20°C) in laboratory settings, only an estimated 5-10% of its activity may remain viable at ambient room temperatures within products.
Safety
Safety Profile
SH-Oligopeptide-9 is generally regarded as safe when used in appropriate concentrations as recommended by manufacturers. It exhibits low concern for cancer, allergies, immunotoxicity, and developmental or reproductive toxicity, and is not present on EWG's Skin Deep Restricted or Unacceptable Lists.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While offering a promising mechanism for skin rejuvenation and hydration, the significant formulation challenges in preserving its active state at room temperature limit the certainty of its practical efficacy, rendering it an optional ingredient.
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References
Sources