Science
Mechanism of Action
This precision peptide functions by replicating the human SOD1 enzyme, a potent endogenous antioxidant. It specifically targets and decomposes superoxide radicals (O2•−), converting them into less reactive hydrogen peroxide (H2O2). This action mitigates oxidative damage, reduces inflammation, and supports the skin's natural repair processes at a cellular level.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As an enzymatic protein, SH-OLIGOPEPTIDE-60 requires careful formulation to preserve its activity and stability. It is susceptible to degradation from both chemical and physical stressors within a cosmetic matrix.
Safety
Safety Profile
While SH-OLIGOPEPTIDE-60 itself lacks explicit CIR, SCCS, or FDA review, its biological analog, Superoxide Dismutase (SOD), is widely recognized as safe for topical cosmetic use. It carries a low hazard rating from EWG, indicating minimal concerns for irritation or sensitization within typical application concentrations (0.1% to 1%). The EU COSING database supports its inclusion in leave-on products for antioxidant and skin conditioning benefits. As an enzyme, systemic absorption risk is low; however, individuals with heightened sensitivities may consider patch testing.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-OLIGOPEPTIDE-60 is a valuable antioxidant ingredient, leveraging a potent enzymatic mechanism to protect skin from oxidative stress and support repair across all skin types.
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References
Sources