Science
Mechanism of Action
This peptide functions by mimicking a segment of the SNAP-25 protein, a critical component of the SNARE complex responsible for neurotransmitter release. By competitively binding to the SNARE complex, SH-OCTAPEPTIDE-3 interferes with its proper assembly and stability. This action effectively inhibits the neuronal exocytosis of neurotransmitters, including acetylcholine and glutamate, which signal muscle contractions. The result is a reversible relaxation of facial muscles, leading to a visible reduction in the depth and prominence of expression lines, akin to a 'Botox-like' effect but through a non-paralytic mechanism.
Research
Clinical Evidence
High confidence0.005%
Transparency
Dusting Analysis
Clinical efficacy has been demonstrated at relatively low concentrations of the pure peptide (e.g., 0.005%), suggesting that even small, effective inclusions are impactful and it is not inherently prone to being 'dusted' if formulated correctly.
The Formula
Formulation
Stability
For optimal stability, Acetyl Octapeptide-3 solutions should be stored in a cool, dark environment at 2-8°C. During formulation, it is crucial to incorporate the ingredient during the cool-down phase (below 40°C) to prevent degradation from high heat.
Synergies
- Leuphasyl (demonstrated synergistic inhibition of muscle contraction)
Safety
Safety Profile
Specific safety reviews by the Cosmetic Ingredient Review (CIR) for SH-OCTAPEPTIDE-3 (Acetyl Octapeptide-3) are not currently available. Despite this, the ingredient is generally recognized as non-irritating for topical use. CIR reports exist for related peptides, but do not directly cover this specific compound.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-OCTAPEPTIDE-3 is a valuable active ingredient for precision skincare, offering clinically validated efficacy in reducing expression lines by modulating muscle contractions without causing paralysis, and exhibits broad skin compatibility.
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