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Moumoujus

SH-HUMANIN SP.

Insufficient Data / ANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

SH-HUMANIN SP is a recombinant human peptide derived from Humanin, a small mitochondrial peptide. It is recognized for its potent cytoprotective properties, preserving cellular health and viability under various stress conditions. This ingredient offers promising benefits for skin resilience and longevity.

Summary

Cytoprotective Antioxidant Anti-inflammatory Anti-aging Mitochondrial Support UV Protection Skin Recovery Cell Viability Enhancement Epidermal Stem Cell Survival

Science

Mechanism of Action

SH-HUMANIN SP functions as a cytoprotective agent primarily by sustaining mitochondrial integrity and enhancing cell viability, especially in stressful or senescent states. It mitigates cellular damage through several pathways: reducing inflammation, neutralizing oxidative stress, and exerting anti-apoptotic effects by decreasing pro-inflammatory DAMPs and interacting with the apoptosis-inducing protein Bax. Specifically, analogues such as S14G-humanin (HNG) have demonstrated efficacy in suppressing UV-B-induced reactive oxygen species (ROS) and boosting antioxidant glutathione expression, thereby protecting against UV-B-mediated cytotoxicity and promoting epidermal stem cell survival. Its activity is partly mediated through the STAT3 pathway, maintaining mitochondrial membrane potential and stem cell characteristics. Humanin can operate via both intracellular pathways to enhance mitochondrial function and extracellular pathways by activating cell surface receptors.

Research

Clinical Evidence

Medium confidence
Effective range 10 µg/mL–13.5 µg/mL%
Optimal

N/A

Key findings

  1. 01 Demonstrated optimal efficacy in protecting human neuroblastoma cells (SH-SY5Y) from toxicity induced by silver nanoparticles, indicating robust cytoprotective capabilities.
  2. 02 Identified as the minimum effective concentration for Humanin fused with elastin-like polypeptide (HN-V96) to provide dose-dependent cell protection by inhibiting caspase-3 activation in human retinal pigment epithelial cells. Unmodified Humanin showed similar protective effects at 10 µg/mL (3.7 µM).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While native Humanin is inherently hydrophobic, SH-HUMANIN SP, as a recombinant human peptide, is typically engineered for enhanced water solubility in cosmetic formulations. However, stability concerns have been reported for certain Humanin analogs (HNG), necessitating specialized stabilization solutions to maintain peptide structural integrity for periods up to 28 days at both 4°C and 37°C, suggesting potential degradation risks without appropriate formulation strategies.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Humanin is currently classified for research use only and is not approved for general human use or in sports, meaning it should be sourced exclusively under 'Research Use Only' guidelines. Endogenous humanin is generally regarded as safe; however, its physiological effects can vary based on context and potentially sex. Comprehensive clinical human testing has not been conducted for SH-HUMANIN SP in a cosmetic context, and therapeutic dosing has not been established. There are no specific CIR or SCCS reviews available for SH-HUMANIN SP or Humanin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting significant cytoprotective, antioxidant, and anti-inflammatory potential in in vitro studies, the lack of human clinical data and regulatory approval for cosmetic use means further research is essential before widespread integration.

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