Science
Mechanism of Action
This extract exerts its effects through phytochemicals that demonstrate antioxidant activity and anti-inflammatory properties by inhibiting lipopolysaccharide-induced nitric oxide production in macrophages. These compounds can also contribute to antibacterial actions and modulate general skin immunity processes, promoting a healthier skin environment.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No specific data suggests this ingredient is commonly 'dusted' at ineffective concentrations. However, due to significant safety concerns and lack of established effective concentrations, any inclusion would require robust validation.
The Formula
Formulation
Safety
Safety Profile
The Senecio genus, including Senecio cannabifolius, is known to contain pyrrolizidine alkaloids (PAs). These compounds are associated with significant inherent toxicity, including hepatotoxic and carcinogenic potential. Stringent dosage control is imperative to prevent potential irreversible harm from overuse. Studies on other Senecio species have shown liver and kidney damage in animal models following aqueous extract administration. No maximum safe concentration for cosmetic use has been established, and it has not been reviewed by the CIR.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite potential anti-inflammatory and antioxidant benefits, the significant inherent toxicity from pyrrolizidine alkaloids and the absence of established safe cosmetic concentrations make this ingredient unsuitable for precision skincare formulations.
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References
Sources