Science
Mechanism of Action
This extract contributes to skin conditioning, primarily through the actions of its isolated constituents. 4-Hydroxybenzoic acid has been shown to selectively inhibit elastase release, demonstrating anti-inflammatory properties, while 3,4-Dihyroxybenzoic acid selectively inhibits superoxide anion generation, acting as an antioxidant. Traditional applications of 'Tiankuizi' also suggest anti-inflammatory, anti-neoplastic, and antibacterial activities.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 4-Hydroxybenzoic acid, an isolated constituent from the root, selectively inhibited elastase release with an IC50 of 3.20 microg/mL, demonstrating 7-fold greater activity than the positive control.
- 02 3,4-Dihyroxybenzoic acid, an isolated constituent from the root, selectively inhibited superoxide anion generation with an IC50 of 6.21 microg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Semiaquilegia Adoxoides Root Extract. It is registered with the FDA's Substance Registry System (SRS), but dermal toxicity data is currently unavailable.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While showing promising in vitro activity for anti-inflammatory and antioxidant benefits through its constituents, comprehensive data on the extract's efficacy and safety in topical formulations is currently lacking.
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References
Sources