SEBACIC ACID.

Sebacic acid operates through multiple pathways to improve skin health. It precisely regulates the overproduction of sebum, effectively diminishing shine, reducing the formation of clogged pores, and helping prevent acne breakouts without inducing dryness. It exhibits a mild antibacterial effect against *Cutibacterium acnes*, a key bacterium implicated in acne development. Furthermore, sebacic acid promotes gentle cellular turnover by encouraging the shedding of dead skin cells, leading to a refined and smoother skin texture. It significantly supports the skin's barrier function by preserving the integrity of its lipid layer and enhancing hydration retention, thereby minimizing transepidermal water loss (TEWL). Preliminary *in vitro* studies suggest its potential to cross-link with collagen type I, which could contribute to improved skin elasticity and mechanical strength. It also demonstrates anti-inflammatory properties by reducing lipopolysaccharide (LPS)-induced expression of interleukin-6 (IL-6) mRNA in macrophage-like cells. However, it is important to note that sebacic acid can be metabolized by human neutrophils into a 5-oxo analog, a compound known to activate pro-inflammatory cells, which might potentially exacerbate inflammatory skin conditions under certain circumstances.