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Moumoujus

SATURATED METHYLENE DIPHENYL DIISOCYANATE.

Avoid CAS 5124-30-1 / NOT REPORTED

This highly reactive diisocyanate is primarily utilized in industrial applications for polymer production. It is not designed for direct application to the skin and carries significant risks of irritation and allergic reactions, making it unsuitable for cosmetic use.

Summary

Science

Mechanism of Action

Saturated Methylene Diphenyl Diisocyanate interacts readily with biological macromolecules such as hydroxyl, sulfhydryl, and amine groups found in skin proteins (e.g., keratin, laminin) and other cellular components. This chemical reactivity leads to the formation of conjugates, which can provoke immune responses, resulting in dermal irritation and sensitization.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

As a highly reactive chemical intermediate, this ingredient is not intended for direct cosmetic use, rendering typical dusting considerations for finished products irrelevant.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This compound is highly unstable in the presence of water, including atmospheric moisture, undergoing hydrolysis to form insoluble polyureas. Therefore, it is incompatible with aqueous formulations, and an optimal pH for stability in such systems is not applicable for the unreacted monomer.

Conflicts

  • Water
  • Alcohols
  • Amines
  • Thiols
  • Compounds with active hydrogen groups
  • Nucleophiles

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Sensitization risk High

Saturated Methylene Diphenyl Diisocyanate is a potent dermal and inhalation sensitizer, known to induce skin irritation and allergic reactions. Direct skin contact can manifest as discoloration, redness, swelling, itching, and dermatitis. Animal studies confirm its irritant potential for skin and eyes. Due to its severe reactivity and hazards, its unreacted monomeric form is explicitly deemed unsafe for direct application in cosmetic formulations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

This highly reactive diisocyanate is a severe dermal irritant and sensitizer, entirely unsuitable and unsafe for any cosmetic application at a 0% concentration limit.

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