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Moumoujus

SARGASSUM PALLIDUM EXTRACT.

Insufficient Data / ANTIOXIDANT

Sargassum Pallidum Extract, sourced from brown algae, is a versatile ingredient distinguished by its potent antioxidant and anti-inflammatory capabilities. Enriched with diverse bioactive compounds, it actively works to mitigate oxidative stress, calm skin irritation, and enhance overall dermal well-being, simultaneously supporting barrier integrity and promoting a luminous complexion.

Summary

Antioxidant Anti-inflammatory Humectant Skin-Conditioning Brightening Skin Barrier Support Cell Renewal Booster

Science

Mechanism of Action

Sargassum Pallidum Extract exerts its effects through a complex array of bioactive molecules, including fucoidan, fucoxanthin, terpenoids, flavonoids, and meroterpenoids. Its significant antioxidant capacity is achieved by neutralizing reactive oxygen species (ROS) and stimulating Nrf2-mediated antioxidant enzyme pathways. Anti-inflammatory properties arise from its ability to downregulate pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, alongside inhibiting the ERK1/2/p38 inflammatory signaling cascade. Furthermore, the extract contributes to skin brightening by inhibiting tyrosinase activity and reducing ROS levels, fortifies the skin barrier, and offers moisturizing benefits due to its inherent hygroscopic nature. It also appears to stimulate microcirculation and accelerate cellular renewal.

Research

Clinical Evidence

Medium confidence
Effective range 15.6–75%
Optimal

N/A

Key findings

  1. 01 In vitro investigations revealed a dose-dependent reduction in reactive oxygen species (ROS) production within TNF-α/IFNγ-stimulated HaCaT keratinocytes, effective at concentrations ranging from 15.6 to 62.5 µg/mL.
  2. 02 Further in vitro research on LPS-stimulated RAW264.7 cells demonstrated anti-inflammatory effects, evidenced by a reduction in intracellular nitric oxide (NO), ROS, and various inflammatory mediators at concentrations between 25 and 75 µg/mL. When incorporated into emulsion and cream formulations, human volunteer studies indicated improvements in skin parameters such as oiliness and elasticity, though precise in-product concentrations were not specified for the human studies.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This algal extract is notably hygroscopic. High concentrations of ethanol may compromise the stability of its polyphenolic components by interfering with hydrogen bonds and hydrophobic interactions, suggesting that water-based formulations are optimal for maintaining its active profile.

Conflicts

  • High concentrations of ethanol

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has determined that there is insufficient data to definitively conclude the safety of Sargassum Pallidum Extract for cosmetic applications. Specifically, reviews conducted in 2019 and 2022 highlighted a lack of systemic toxicity data (such as GRAS status or oral exposure) and dermal sensitization data for brown algae-derived ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While initial in vitro studies and limited human volunteer data suggest promising antioxidant, anti-inflammatory, and skin-conditioning benefits, the Cosmetic Ingredient Review (CIR) Expert Panel has found insufficient data to conclusively establish its safety for cosmetic use.

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References

Sources