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Moumoujus

SARGACHROMANOL C.

Insufficient Data CAS - / SKIN CONDITIONING

Sargachromanol C, a meroterpenoid derived from brown algae, exhibits significant potential in precision skincare. Research, primarily on related sargachromanol compounds, indicates robust anti-inflammatory, antioxidant, and photoprotective properties through distinct cellular mechanisms. It shows promise in mitigating oxidative stress, reducing inflammatory responses, and protecting against UVA-induced skin aging.

Summary

Antioxidant Anti-inflammatory Anti-aging Photoprotection Skin whitening/brightening Skin barrier repair Moisturizing

Science

Mechanism of Action

Sargachromanol C and related compounds modulate skin cellular processes by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS), which are key drivers of inflammation and oxidative damage. Its anti-inflammatory action involves activating the Nrf2/HO-1 signaling pathway and suppressing NF-κB activation and MAPK phosphorylation, leading to a reduction in pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6) and inflammatory mediators (e.g., iNOS, COX-2, PGE2). For photoprotection and anti-aging, it reduces UVA-enhanced AP-1 transcriptional activation, thereby decreasing the expression of matrix metalloproteinases (MMP-1, MMP-2, MMP-9) and limiting UVA-induced intracellular ROS, membrane protein oxidation, and lipid peroxidation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Sargachromenol, a closely related compound, at concentrations ranging from 7.8 to 62.5 µg/mL, significantly inhibited LPS-induced nitric oxide (NO) and reactive oxygen species (ROS) production in RAW 264.7 macrophages (in vitro), without causing cytotoxicity, demonstrating potent anti-inflammatory effects.
  2. 02 Sargachromanol G, another related compound, at 10, 20, and 40 µM, dose-dependently reduced the production of inflammatory markers (NO, iNOS, PGE2, COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in LPS-stimulated RAW 264.7 cells (in vitro).
  3. 03 Sargachromenol and Sargachromanol E effectively reduced UVA-induced intracellular ROS production, membrane protein oxidation, and lipid peroxidation in human dermal fibroblasts (HDF cells) (in vitro). They also inhibited the expression of MMP-1, MMP-2, and MMP-9, suggesting protective benefits against photo-aging.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Sargachromanol C is highly lipophilic, similar to Sargachromanol E which has very low water solubility (estimated 0.0008333 mg/L at 25 °C). Its isolation from Sargassum species typically employs organic solvents like n-hexane, ethyl acetate, and chloroform, confirming its oil-soluble nature.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not specifically evaluated Sargachromanol C. While some brown algae-derived ingredients have been deemed safe in general assessments, the specific safety profile of Sargachromanol C for cosmetic application remains undetermined.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Sargachromanol C demonstrates promising *in vitro* efficacy as an anti-inflammatory, antioxidant, and photoprotective agent, but its specific safety profile and optimal concentration for human skin application require further dedicated research.

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