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Moumoujus

SARGACHROMANOL B.

Insufficient Data CAS - / SKIN CONDITIONING

Sargachromanol B is a chromanol derivative lauded for its robust antioxidant and anti-inflammatory capabilities. This ingredient is designed to actively combat oxidative stress and soothe inflammatory responses, fostering a resilient and healthy skin barrier.

Summary

Antioxidant Anti-inflammatory Skin conditioning Anti-aging Photoprotective

Science

Mechanism of Action

The operational mechanism of Sargachromanol B, corroborated by studies on related chromanols, involves comprehensive cellular protection. It activates the Nrf2/HO-1 signaling pathway, substantially reducing nitric oxide (NO) and reactive oxygen species (ROS) to counter oxidative damage. Furthermore, it modulates inflammatory cascades by suppressing NFκB and MAPK pathways, which in turn decreases the expression of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, alongside inflammatory mediators like iNOS and COX-2. Evidence from related chromanols also suggests photoprotective benefits, including the mitigation of UVA-induced intracellular ROS, prevention of membrane protein and lipid oxidation, inhibition of matrix metalloproteinases (MMP-1, MMP-2, MMP-9), and an increase in tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2), contributing to anti-aging effects.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Sargachromenol, a related compound, demonstrated significant increases in cell viability and reductions in nitric oxide and intracellular reactive oxygen species at concentrations of 7.8–62.5 µg/mL in LPS-stimulated RAW 264.7 macrophages. It also decreased mRNA expression of inflammatory cytokines (IL-1β, IL-6, TNF-α) and mediators (iNOS, COX-2).
  2. 02 Sargachromanol E, another related chromanol, suppressed UVA-induced intracellular ROS formation, membrane protein oxidation, and lipid peroxidation in human dermal fibroblasts. It also inhibited the expression of collagenases (MMP-1, MMP-2, MMP-9) while increasing tissue inhibitor of metalloproteinase (TIMP-1, TIMP-2) expression and inhibiting AP-1 signaling.
  3. 03 Sargachromanol G, also a related chromanol, dose-dependently inhibited inflammatory markers (nitric oxide, iNOS, PGE2, COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) at 10, 20, and 40 µM in LPS-stimulated RAW 264.7 cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Sargachromanol B is recognized as a cosmetic skin conditioning agent. However, no specific safety assessments by CIR or SCCS have been identified. While related compounds, Sargachromenol and Sargachromanol E, did not exhibit cytotoxicity in in-vitro studies at tested concentrations, comprehensive toxicity data for Sargachromanol B itself is not currently available.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Sargachromanol B demonstrates promising antioxidant and anti-inflammatory properties, with related chromanols showing significant efficacy in mitigating oxidative stress and inflammation, yet direct clinical data for this specific compound is currently limited.

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