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Moumoujus

SANTALYL ACETATE.

Optional CAS 1323-00-8 / PERFUMING

Santalyl Acetate is an aromatic ester primarily incorporated into skincare formulations as a perfuming agent. It contributes a characteristic woody and floral scent, reflecting its derivation from santalol, a key component of sandalwood oil. Its interaction with skin involves enzymatic hydrolysis, potentially releasing its parent alcohol.

Summary

Perfuming

Science

Mechanism of Action

This ingredient functions principally as a fragrance component. Upon contact with the skin, Santalyl Acetate, an ester, can undergo enzymatic hydrolysis catalyzed by skin esterases, leading to the formation of its parent alcohol, santalol. Consequently, any potential biological activity on the skin, such as the chemopreventive properties observed for alpha-santalol in some academic mouse studies, would be mediated by the hydrolyzed form rather than the intact ester.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no data to suggest that Santalyl Acetate presents 'dusting' concerns in cosmetic applications. Its primary role as a liquid fragrance component does not align with typical dusting ingredient profiles.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Santalyl Acetate exhibits good stability across a diverse range of cosmetic vehicles, including creams, lotions, hair sprays, lipsticks, powders, and soaps, generally without causing discoloration.

Conflicts

  • Formulators must consider that esters like Santalyl Acetate can be hydrolyzed by skin esterases into their parent alcohols. If the resultant alcohol is a known sensitizer, this transformation is a critical formulation consideration.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The European Food Safety Authority (EFSA) concluded that Santalyl Acetate does not pose genotoxicity concerns. The SCCS (Scientific Committee on Consumer Safety) evaluated human data, finding it is not considered among common fragrance allergens and projecting a low risk of skin sensitization. However, the SCCS cautions that substances capable of transforming into known contact allergens should be treated equivalently. While PubChem indicates it is 'Not Classified' for most hazards in 99.6% of reports, older European hazard information did suggest potential irritation to skin and eyes (R 36/38). In the U.S., cosmetic ingredients generally do not require pre-market FDA approval.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Santalyl Acetate serves as an optional perfuming agent, valued for its stable woody-floral aroma and generally low sensitization risk, though its potential hydrolysis to santalol requires careful consideration during formulation.

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