Science
Mechanism of Action
It acts as a selective agonist for the OR2AT4 olfactory receptor, prolonging the hair growth phase and suppressing apoptosis in follicles. In keratinocytes, OR2AT4 activation enhances cell proliferation, migration, and dermcidin synthesis, aiding wound repair and microbiome balance.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates telogen effluvium: Randomized, double-blinded, placebo-controlled trial.
- 02 Application of Topical Sandalore® Increases Epidermal Dermcidin Synthesis in Organ-Cultured Human Skin ex vivo - PubMed.
Transparency
Dusting Analysis
While used as a fragrance at low levels, effective concentrations for active skin and hair benefits, such as 1% for hair growth, indicate it is not typically 'dusted' when used for performance.
The Formula
Formulation
Stability
Sandalore is chemically robust and stable across a wide pH range (4-9), resisting heat and UV degradation. It performs well in various applications, including shampoos and bar soaps.
Conflicts
- Acid cleaners
- Very alkaline products
Safety
Safety Profile
It is not restricted under EU regulations and is considered non-sensitizing. However, the raw material carries GHS hazard statements for serious eye irritation and aquatic toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With compelling evidence for hair growth, wound healing, and microbiome benefits, Sandalore presents a valuable multi-functional ingredient for targeted skincare and haircare applications.
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References
Sources
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