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Moumoujus

SAMBUCUS EBULUS FLOWER EXTRACT.

Valuable CAS 85940-37-0 / SKIN CONDITIONING

Sambucus ebulus Flower Extract is a botanical ingredient recognized for its comprehensive dermatological benefits, including potent anti-inflammatory, antioxidant, and wound-healing actions. This extract specifically targets inflammatory pathways, combats oxidative stress, and supports skin regeneration, making it a promising candidate for formulations addressing sensitive or compromised skin conditions.

Summary

Anti-inflammatory Antioxidant Wound healing Skin conditioning Antibacterial

Science

Mechanism of Action

This extract operates through multiple pathways to benefit the skin. It exhibits significant anti-inflammatory effects by suppressing the biosynthesis of pro-inflammatory cytokines such as tumor necrosis factor–α (TNF-α), interleukin 1-α (IL1-α), and interleukin 1-β (IL1-β). Furthermore, it inhibits TNF-stimulated expression of vascular cell adhesion molecule 1 (VCAM-1), with its anti-inflammatory role partly attributed to ursolic acid's interaction with the COX-2 pathway. Its rich content of flavonoids and phenols provides robust antioxidant protection, shielding the skin from oxidative damage. The extract also promotes wound healing, a benefit potentially linked to the presence of quercetin 3-O-glucoside, and demonstrates antibacterial activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

10%

Key findings

  1. 01 Demonstrated considerable wound healing activity in an animal model (rats) for both linear and circular excisions, attributed to quercetin 3-O-glucoside.
  2. 02 Formulated in a topical gel, it showed a significant effect in treating knee osteoarthritis in a randomized double-blind active-controlled clinical trial, comparable to 1% diclofenac gel.
  3. 03 Topical use was found to be as effective as hydrocortisone in reducing the severity of hand eczema in a double-blind randomized controlled trial.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A 10% aqueous extract of Sambucus ebulus has been successfully incorporated into a gel formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Sambucus ebulus flower extract has not been reviewed by the Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS). While extracts from related species (Sambucus canadensis L. or Sambucus nigra L.) are listed by the FDA as Generally Recognized As Safe (GRAS) for flavor, this status does not extend to S. ebulus. Research indicates the presence of biologically active compounds, with some studies mentioning 'Separation of Active and Toxic Poisons,' suggesting the need for careful assessment regarding its safety profile for cosmetic application. Despite this, it has shown efficacy in treating hand eczema, suggesting potential tolerability for sensitive skin in certain formulations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sambucus ebulus flower extract presents significant anti-inflammatory and reparative properties, with human clinical support for specific skin concerns, warranting further safety validation for broader cosmetic use despite its potential.

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