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Moumoujus

SALVIA OFFICINALIS OIL.

Valuable CAS 8022-56-8 / 84776-73-8 / FRAGRANCE, TONIC

Salvia Officinalis Oil, derived from common sage, offers purifying and soothing properties for the skin. It helps regulate excess oil production, minimizes pore appearance, and provides antioxidant protection, contributing to overall skin clarity and vibrance.

Summary

Purifying Soothing Astringent Antioxidant Antiseptic Antibacterial Anti-inflammatory Sebum Regulation Skin Renewal Masking Tonic

Science

Mechanism of Action

This oil functions by moderating sebum production, which helps prevent clogged pores. It exerts a calming effect on irritated or inflamed skin and acts as an astringent to refine skin texture and tighten pores. Rich in antioxidants, it defends skin against free radical damage. Additionally, it contributes to skin renewal and possesses antiseptic, antibacterial, and anti-inflammatory attributes.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated antifungal efficacy against dermatophyte strains and significantly reduced nitric oxide (NO) production in LPS-stimulated macrophages, indicating anti-inflammatory potential, without adverse effects on cell viability.
  2. 02 Inhibited C32 human melanoma cell lines in vitro, suggesting potential cytotoxic effects on certain cancer cells.
  3. 03 Inhibited ACHN renal carcinoma cell lines in vitro, indicating similar cytotoxic potential.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.064%
Red flag below
0.02%

While Salvia Officinalis Oil offers various benefits, its maximum recommended cosmetic use concentration is 0.02%. This is below the 0.064% (0.64 μL/mL) concentration shown effective for specific anti-inflammatory and antifungal activities in vitro. Therefore, claims for these more potent biological effects in finished products formulated at or below the 0.02% safety limit may be considered an overstatement of the ingredient's contribution.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

The oil is soluble in alcohol and miscible with most fragrance components, performing well in both alcohol- and oil-based systems. It can be stabilized in aqueous solutions when properly solubilized. It exhibits good oxidative stability due to natural antioxidants but is vulnerable to thujone degradation upon prolonged UV exposure. Storage in amber glass, away from light and heat, is critical for its typical 2-3 year shelf life.

Conflicts

  • High concentrations of terpenes/terpenoids are associated with a risk of dermal sensitization.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.02%%
Sensitization risk Moderate

The CIR Expert Panel deems Salvia officinalis ingredients safe for cosmetic use when formulated to be non-sensitizing. Concerns stem from terpenes/terpenoids, which can be dermal sensitizers at high levels. Undiluted oil caused moderate irritation on rabbit skin and one instance in a human patch test, though an 8% concentration in petrolatum showed no irritation or sensitization in human tests. The FDA recognizes sage as GRAS for food applications. The maximum reported cosmetic use concentration for the oil is 0.02%.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Salvia Officinalis Oil is a valuable ingredient for addressing oiliness, inflammation, and supporting skin clarity, provided it is formulated carefully within recommended concentrations to mitigate moderate sensitization risks from its terpene content.

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