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Moumoujus

SALIVARY GLAND EXTRACT.

Insufficient Data / SKIN CONDITIONING, SKIN PROTECTING

Salivary Gland Extract is a complex biological blend sourced from animal salivary glands, containing elements like growth factors, enzymes, electrolytes, and mucins. Preliminary research indicates its capacity to stimulate skin cell proliferation and metabolic activity, suggesting a role in supporting the skin's regenerative and healing processes.

Summary

Wound Healing Support Cell Proliferation Stimulant Regenerative Potential Skin Conditioning

Science

Mechanism of Action

This extract operates by actively promoting cellular proliferation, notably enhancing the metabolic activity and growth of cultured human keratinocytes and murine fibroblasts. Its efficacy is attributed to potential growth factors and other bioactive components, which initiate increased DNA synthesis and overall cellular activity crucial for tissue regeneration and repair.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies on cultured human keratinocytes (HaCat) and murine fibroblasts (3T3) demonstrated stimulated proliferation and metabolic activity when exposed to rat salivary gland extract at concentrations of 1-10 µg protein/ml, indicating potential benefits for wound healing.
  2. 02 In vivo administration of 4.0 mg tissue protein of salivary gland extract in 0.1 M-sodium phosphate buffer, twice daily for 15 days, to rats resulted in an increased rate of DNA synthesis and total mucosal DNA and RNA content in the oxyntic mucosa, highlighting a role in tissue growth and regeneration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for cosmetic formulation stability are not documented. Natural saliva maintains a pH typically between 5.6 and 7.8, supported by buffering systems. While a neutral pH of 7.0 was noted for a specific extract preparation using PBS, this does not dictate long-term cosmetic stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Comprehensive safety assessments for 'Salivary Gland Extract' in cosmetic applications by regulatory bodies such as CIR, SCCS, or FDA are currently unavailable. Therefore, specific data regarding irritation, sensitization, or overall safety profile in human topical use is lacking.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite compelling in vitro and animal study data suggesting regenerative and wound-healing properties through enhanced cellular activity, the absence of direct human clinical efficacy and comprehensive safety evaluations for cosmetic use places Salivary Gland Extract in a category of insufficient data for a definitive recommendation.

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References

Sources