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Moumoujus

SAGERETIA THEA LEAF EXTRACT.

Valuable / SKIN CONDITIONING

Sageretia Thea Leaf Extract is a botanical active recognized for its potential to address multifaceted skin concerns. Research indicates its capacity to mitigate hyperpigmentation, soothe inflammatory responses, and provide robust antioxidant protection, contributing to a visibly more even-toned and resilient complexion.

Summary

Antioxidant Skin-conditioning Anti-inflammatory Brightening

Science

Mechanism of Action

This extract operates through several distinct biological pathways within the skin. It exhibits anti-melanogenic effects by suppressing melanin content and intracellular tyrosinase activity via the downregulation of tyrosinase, TRP1, and MITF expression, a process potentially mediated by the Akt/GSK3β signaling pathway. Concurrently, it acts as a potent anti-inflammatory agent by inhibiting the production of key pro-inflammatory mediators such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). This anti-inflammatory action is further supported by blocking NF-κB activation and attenuating the phosphorylation of ERK1/2, p38, and JNK, while also upregulating heme oxygenase-1 (HO-1) expression. Additionally, the extract provides antioxidant benefits by inhibiting the oxidation of low-density lipoprotein.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract contains a complex array of components, demonstrating solubility in both polar (e.g., methanol, n-butanol) and non-polar (e.g., n-hexane) solvents, which suggests versatility for integration into various formulation types.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments for SAGERETIA THEA LEAF EXTRACT have been conducted by the Cosmetic Ingredient Review (CIR), and its FDA status for cosmetic use is not yet available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sageretia Thea Leaf Extract is a valuable botanical ingredient offering scientifically supported anti-inflammatory, antioxidant, and potential brightening benefits, making it a promising addition for addressing various skin concerns, despite limited human clinical data.

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