Science
Mechanism of Action
These polypeptides function by signaling the body to activate its endogenous skin repair systems. They actively promote the synthesis of essential skin proteins, including collagen, which leads to improved skin elasticity and firmness, thereby reducing the appearance of fine lines and wrinkles. Additionally, they boost the production of vital skin components such as hyaluronic acid, elastin, and fibronectin, contributing to enhanced moisture retention, a strengthened skin barrier, and a more revitalized complexion. The ingredient also exhibits antioxidant and anti-inflammatory properties, and in hair care, aids in fiber strengthening, regeneration, and scalp microbiota balance.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
Specific data on the typical 'dusting' concentrations or thresholds for Saccharomyces Polypeptides in cosmetic formulations is not available within the provided research.
The Formula
Formulation
Stability
Peptides derived from Saccharomyces cerevisiae are reported to be thermostable and maintain steady activity within a pH range of 4-7. However, peptides in general are susceptible to degradation influenced by pH variations, solvent environment, oxidation, and temperature. Aggregation is a primary concern, which can be affected by pH, ionic strength, concentration, and temperature. To ensure product integrity, formulations should avoid repeated freeze-thaw cycles, and maintain a pH not lower than 3.0 to prevent hydrolysis.
Conflicts
- Formulating outside the optimal pH range of 4-7 or using unsuitable solvent systems may lead to precipitation, reduced solubility, or denaturation of the polypeptides.
- Combinations with strong reducing agents or redox-sensitive ingredients (e.g., specific copper peptides) should be avoided unless compatibility is thoroughly verified through prior studies.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has issued an 'Insufficient Data Announcement' for a broader category of yeast-derived ingredients, including those from Saccharomyces cerevisiae. The panel requested additional data, specifically confirmatory dermal sensitization data, information on food use/Generally Recognized As Safe (GRAS) status for cosmetic applications, or 28-day dermal toxicity data. While Saccharomyces cerevisiae (baker's yeast) holds GRAS affirmation from the US FDA for food use up to 5%, a definitive safety assessment concluding 'safe as used' for 'Saccharomyces Polypeptides' in cosmetics is not yet established.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Saccharomyces Polypeptides demonstrate promising in vitro efficacy in collagenase inhibition and antimicrobial properties across various skin types; however, a comprehensive 'safe as used' conclusion for cosmetic applications is pending further regulatory safety data.
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