Science
Mechanism of Action
This ingredient works by stimulating the skin's natural renewal processes, boosting cell turnover, and enhancing oxygen consumption at a cellular level, thereby promoting energy production and regeneration. It acts as a potent antioxidant, neutralizing free radicals and offering protection from environmental damage. Rich in amino acids, vitamins, and minerals, it nourishes and hydrates the skin, improving elasticity and supporting the natural protective barrier. Furthermore, Saccharomyces Lysate exhibits anti-inflammatory and anti-irritant properties, helping to calm and heal stressed skin. As a postbiotic, its by-products contribute to normalizing the skin's microbiome by controlling harmful microorganisms, and it may also boost the absorption of other active ingredients and enhance overall nutrient density.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 At 0.01% (v/v), fermentation residue of S. cerevisiae notably increased skin brightness (L* values) over three weeks in a double-blind clinical trial.
- 02 Concentrations between 0.1% and 2.8% are deemed sufficient for a discernible effect, with 1.0% specifically recommended for optimal results.
- 03 A 2.5% concentration was utilized in a clinical study involving 50 participants, indicating its relevance in efficacy trials.
- 04 Typical use levels in cosmetics range from 1% to 5%.
Transparency
Dusting Analysis
Saccharomyces Lysate demonstrates clinical efficacy at concentrations as low as 0.01% for specific benefits. While typical cosmetic use often extends up to 5%, the CIR Panel has noted its use up to 0.067% specifically in baby products. The CIR's ongoing review of 'Yeast-Derived Ingredients' under an 'Insufficient Data Announcement' indicates a nuanced regulatory landscape regarding higher concentrations, particularly for sensitive applications, but does not suggest common use at ineffective levels for adult skincare.
The Formula
Formulation
Stability
For optimal stability, this ingredient should be thoroughly stirred or blended with the water portion of the formulation. To prevent degradation, avoid exposing it to heat, and incorporate it as a final step if the overall formula requires heating during mixing.
Synergies
- Enhances the absorption of other active ingredients
- Increases nutrient density in the skin
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Panel has issued an 'Insufficient Data Announcement' (IDA) for the broader category of 'Yeast-Derived Ingredients,' indicating an ongoing review. While the CIR status is 'safe with restrictions,' the stated maximum concentration of 0.067% specifically refers to its observed use in baby lotions/oils/powders/creams. Clinical studies and typical cosmetic formulations frequently utilize Saccharomyces Lysate at much higher concentrations, ranging from 0.1% to 5%, without reported issues in healthy adults. Case reports of yeast-related infections were primarily in immunocompromised or post-surgical patients, making their relevancy to general cosmetic safety unlikely.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Saccharomyces Lysate is a highly valuable, multifaceted ingredient that effectively promotes skin regeneration, hydration, and protection across all skin types, despite current regulatory considerations for a broader ingredient category.
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