Science
Mechanism of Action
The Saccharomyces ferment component functions by delivering vital nutrients and antioxidants to the skin, which can mitigate inflammation, stimulate collagen synthesis, and improve skin elasticity. Its composition, rich in polysaccharides, peptides, essential minerals, amino acids (including glycine and proline), beta-glucan, and vitamins, works to nourish, moisturize, and protect the skin. Amino acids are known to activate aquaporin 3 (AQP3) expression, enhancing the skin's capacity for water absorption, while polysaccharides support tight junction protein synthesis, bolstering the skin's barrier. The precise mechanism or benefit of the fluoride component within this ferment remains undefined by research.
Research
Clinical Evidence
Insufficient-data confidence5%
Key findings
- 01 Continuous application of a spray containing 5% Saccharomyces boulardii fermented product filtrate over four weeks significantly reduced trans-epidermal water loss (TEWL) by an average of 37.2% and increased stratum corneum hydration by 62.5%.
- 02 Topical application of a dried Saccharomyces Cerevisiae ferment reduced histamine-induced skin inflammation, decreased time to maximum blood perfusion, and accelerated inflammation resolution in a placebo-controlled study with 12 volunteers.
- 03 Saccharomyces Ferment Filtrate is generally recommended for leave-on products at concentrations between 0.1% and 5% for its benefits in improving skin health, providing antioxidants, reducing inflammation, boosting collagen, and refining skin texture.
Transparency
Dusting Analysis
While Saccharomyces ferments are well-researched for their skin benefits, the specific combination as 'SACCHAROMYCES/FLUORIDE FERMENT' lacks dedicated efficacy and safety data. Research indicates fluoride can inhibit fermentation, suggesting its inclusion in this specific form may not confer additional benefits and could potentially compromise the primary ferment activity, raising concerns about its functional rationale.
The Formula
Formulation
Stability
Saccharomyces Ferment exhibits stability across a broad pH range of 2.5 to 9.5. For optimal formulation stability, it is advised to incorporate this ingredient during the cooling phase. Storage between 16°C and 32°C, with an optimal range of 23-25°C, is recommended for maximizing shelf life.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has issued an 'Insufficient Data Announcement' for yeast-derived ingredients, requesting further safety data. While Saccharomyces cerevisiae is generally recognized as safe (GRAS) by the FDA for food use up to 5%, specific safety data for 'SACCHAROMYCES/FLUORIDE FERMENT' combining both components is unavailable. Notably, fluoride has been observed to inhibit fermentation, suggesting potential implications for the efficacy and safety profile of this combined ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Saccharomyces ferments generally offer valuable skin benefits, the specific ingredient 'SACCHAROMYCES/FLUORIDE FERMENT' lacks dedicated safety and efficacy data, particularly concerning the fluoride component, which research suggests may inhibit fermentation.
Related
Similar Ingredients
Finding similar ingredients…