Science
Mechanism of Action
The ingredient, derived from fermented Caragana sinica root, functions primarily as an anti-inflammatory agent by inhibiting key pro-inflammatory cytokines, including TNF-α, IFN-γ, IL-6, and MCP-1. This targeted action helps to reduce epidermal hyperplasia and mitigate immune cell infiltration in inflamed tissues. Furthermore, it exhibits notable antioxidant properties, contributing to overall skin protection.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In a mouse model of contact dermatitis, an ethanol extract of Caragana sinica, administered at dosages exceeding 180 μg/day, demonstrated significant reduction in epidermal hyperplasia and immune cell infiltration. This treatment led to a decrease in pro-inflammatory markers (TNF-α, IFN-γ, IL-6, MCP-1), effectively ameliorating skin lesions and inhibiting dorsal skin thickening.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The CIR Panel has issued an 'Insufficient Data Announcement' for the broader category of Yeast-Derived Ingredients in cosmetics, requesting confirmatory dermal sensitization data. While Saccharomyces cerevisiae is generally recognized as safe (GRAS) by the FDA for certain food uses, this status does not directly apply to this specific fermented root extract as a cosmetic ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient exhibits promising anti-inflammatory and antioxidant properties based on preclinical data, yet comprehensive human topical efficacy and safety data are currently insufficient for a definitive assessment.
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References
Sources