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Moumoujus

S-VIPER CYSTEINE-RICH VENOM PROTEIN.

Avoid / SKIN PROTECTING

S-VIPER CYSTEINE-RICH VENOM PROTEIN is a non-enzymatic protein found in snake venom, known for its role in localized toxicity during envenomation. While synthetic mimetics are explored in anti-aging skincare, the natural protein induces inflammatory responses and increases vascular permeability.

Summary

Skin Protecting

Science

Mechanism of Action

As a type of snake venom cysteine-rich secretory protein (svCRiSP), this ingredient operates by inhibiting ion channels and influencing cell-signaling pathways within vascular endothelial cells. Its natural form specifically promotes inflammatory responses, including the infiltration of leukocytes and neutrophils, and elevates vascular permeability. Certain svCRiSPs also trigger caveolin-1 expression in human dermal blood endothelial cells.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted

Despite being listed in common uses for anti-aging, firming, and barrier repair, the natural form of S-VIPER CYSTEINE-RICH VENOM PROTEIN is known to induce inflammation and increase vascular permeability. This suggests that beneficial cosmetic applications likely refer to synthetic analogs or highly modified peptides, not the full natural protein as described, creating a significant discrepancy between perceived benefits and known biological activity.

The Formula

Formulation

Solubility
Water
Optimal pH 1 – 7
0 7 14

Stability

Snake venom cysteine-rich secretory proteins exhibit high stability across a wide pH range, maintaining integrity in strong acidic conditions (below pH 2.0) as well as neutral environments (e.g., pH 7.0) used in purification processes.

Conflicts

  • Potential for pH-dependent complex formation with other ingredients.
  • In its natural form, the ingredient's propensity for inducing pro-inflammatory effects and increasing vascular permeability fundamentally conflicts with typical beneficial skincare applications.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

No specific safety assessments from CIR, SCCS, or FDA exist for S-VIPER CYSTEINE-RICH VENOM PROTEIN as a cosmetic ingredient. Research predominantly highlights the toxicological and pathophysiological effects of natural snake venom cysteine-rich secretory proteins, which are characterized by inflammatory responses and increased vascular permeability.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the documented inflammatory and vascular permeability-increasing effects of S-VIPER CYSTEINE-RICH VENOM PROTEIN in its natural form, it is unsuitable for beneficial cosmetic application, with advertised benefits in skincare likely referring to synthetic mimetics rather than this specific protein.

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