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Moumoujus

S-PENTADIPLANDRA BRAZZEANA DEFENSIN-LIKE PROTEIN.

Insufficient Data / NOT REPORTED

S-Pentadiplandra Brazzeana Defensin-Like Protein, commonly referred to as Brazzein, is a small, cationic protein derived from the Oubli fruit. It structurally mimics defensins, exhibiting robust stability across an extensive pH range and under thermal stress. Its primary action involves targeted interaction with microbial membranes.

Summary

Antimicrobial Antibacterial Antifungal Skin conditioning

Science

Mechanism of Action

Brazzein exerts its biological activity through a defensin-like mechanism, specifically by binding to microbial cell membranes, a process largely driven by its positive charge and interaction with phospholipids. This interaction induces the formation of pore-like structures or oligomerization, leading to the disruption of membrane integrity. The consequence is the efflux of critical ions and nutrients, thereby demonstrating antimicrobial (antibacterial and antifungal) properties against various microbes, including *Bacillus subtilis*, *Staphylococcus aureus*, *Escherichia coli*, and *Candida albicans*. Its antimicrobial efficacy is notably pH-dependent, observed optimally at pH 7.5 rather than pH 5.5.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 0 – 12
0 7 14

Stability

Brazzein exhibits exceptional thermostability, maintaining its integrity even after incubation at 80°C for 4 hours. It is also remarkably stable across a broad pH range, from approximately pH 0 to 12, allowing for versatile formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Brazzein, particularly when produced via *Aspergillus oryzae*, has been granted Generally Recognized As Safe (GRAS) status by the FDA for its use as a sweetener in food, indicating a low risk profile. Generally, plant-derived defensins are considered non-toxic to both plant and mammalian cellular systems.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While S-Pentadiplandra Brazzeana Defensin-Like Protein demonstrates a well-defined antimicrobial mechanism and remarkable stability for formulation, specific clinical efficacy data for targeted skincare applications, particularly concerning optimal concentrations, remains unestablished for precision integration.

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