Science
Mechanism of Action
The precise mechanism of S-HIV-1 Oligopeptide-2 SP in skin is not yet thoroughly defined. However, its close analog, Sh-Oligopeptide-2, also known as Insulin-like Growth Factor 1 (IGF-1), is understood to stimulate cellular proliferation and support wound healing. This activity is notably enhanced when IGF-1 works synergistically with Epidermal Growth Factor (EGF), promoting the robust proliferation of keratinocytes, the primary cells of the epidermis.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Specific stability data for S-HIV-1 Oligopeptide-2 SP as a cosmetic ingredient is currently unavailable. Research related to HIV-1 protease, a related enzymatic protein, suggests optimal activity and stability within the pH 5-6 range, with enhanced stability observed at higher pH levels, achieving 14.5 kcal/mol at pH 5 and 25°C. Separately, HIV-1 capsid stability has been noted at an optimal pH of 7.4. These data points refer to the broader HIV-1 biological context and may offer potential guidance but are not direct assessments for the cosmetic peptide.
Synergies
- Epidermal Growth Factor (EGF)
Safety
Safety Profile
Comprehensive safety assessments from authoritative bodies such as the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for S-HIV-1 Oligopeptide-2 SP as a cosmetic ingredient have not been published. Information from the FDA typically pertains to HIV diagnostic kits or antiretroviral pharmaceuticals, and not to this peptide's use in skincare formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While related peptides exhibit promising regenerative properties, the absence of specific clinical studies and comprehensive safety data for S-HIV-1 Oligopeptide-2 SP in cosmetic applications currently limits a definitive assessment of its efficacy and safety profile.
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References
Sources