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Moumoujus

S-BLACK WIDOW SPIDER HEXAPEPTIDE-1 SP.

Insufficient Data / ANTIOXIDANT, EYELASH CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

S-BLACK WIDOW SPIDER HEXAPEPTIDE-1 SP is a synthetic hexapeptide, a six-amino acid single chain protein. It is inspired by a sequence from Alpha-Latrotoxin-Lt1a, a potent neurotoxin found in the venom of the black widow spider, Latrodectus tredecimguttatus. While its biochemical origin is established, the specific actions of this hexapeptide within a cosmetic context remain largely unexplored.

Summary

Science

Mechanism of Action

This hexapeptide is structurally derived from Alpha-Latrotoxin-Lt1a, a neurotoxin known to induce substantial neurotransmitter release, depolarize neuronal membranes, elevate intracellular Ca2+ levels in nerve terminals, and form ion-permeable pores in lipid membranes. However, the precise mechanism by which S-BLACK WIDOW SPIDER HEXAPEPTIDE-1 SP exerts any effect on the skin within a cosmetic formulation has not been detailed in available research.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

General spider venom peptides often demonstrate notable thermal, chemical, and enzymatic resilience, frequently due to stabilizing disulfide bonds or cystine knot structures. However, specific stability information for S-BLACK WIDOW SPIDER HEXAPEPTIDE-1 SP in cosmetic applications is not available.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) noted the existence of 's-Black Widow Spider Hexapeptide-1 SP' as a 6-amino acid peptide derived from Alpha-Latrotoxin-Lt1a. However, the CIR has not conducted a safety assessment, thus no official safety status (e.g., safe as used, safe with restrictions, insufficient data, or not reviewed) or maximum allowable concentration has been established. No specific opinions from SCCS or status from the FDA were found.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Due to the complete absence of clinical studies, an undefined cosmetic mechanism of action, and an unreviewed safety status, there is currently insufficient data to determine the efficacy or safety of S-BLACK WIDOW SPIDER HEXAPEPTIDE-1 SP for skincare use.

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