Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RUTA GRAVEOLENS LEAF EXTRACT.

Valuable CAS 84929-47-5 / FLAVOURING, FRAGRANCE, PERFUMING

Ruta Graveolens Leaf Extract is a botanical active recognized for its dual action: it provides moderate antibacterial activity against common acne-causing bacteria and delivers potent antioxidant protection. This extract simultaneously works to clarify the complexion while offering significant soothing and protective benefits for overall dermal vitality.

Summary

Antioxidant Antimicrobial Anti-inflammatory Skin-soothing Skin-protective Complexion Clearing Melanin Support Masking Perfuming

Science

Mechanism of Action

This extract leverages a complex profile of bioactive compounds, including alkaloids known for their antimicrobial and anti-inflammatory properties. Flavonoids, such as rutin and quercetin, are powerful antioxidants that defend against free radical damage. Additionally, essential oils contribute therapeutic attributes, while coumarins offer distinct skin-soothing and protective effects. Its comprehensive action helps calm irritated skin, provides a barrier against certain bacterial and fungal agents, and contributes to enhanced skin texture. Furthermore, specific constituents are implicated in supporting healthy melanin production and shielding melanocytes from oxidative stress by downregulating endoplasmic reticulum stress and pro-inflammatory cytokines, culminating in a clearer, more youthful complexion.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in vitro study demonstrated that 50%, 70%, and 90% ethanolic extracts of Ruta Graveolens exhibited moderate antibacterial activity against Staphylococcus epidermidis, Staphylococcus aureus, and Propionibacterium acnes, primary pathogens in acne vulgaris. The 90% extract proved most effective, achieving average Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) of 1.38 mg/mL for P. acnes, and MICs of 2.1 mg/mL and MBCs of 2.86 mg/mL for staphylococcal strains.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

No broad optimal pH range for cosmetic formulation stability has been reported. However, one study noted growth inhibitory effects of the extract around pH 6.0.

Conflicts

  • Direct sun exposure (due to phototoxicity from furanocoumarins like bergapten)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.0015% (15 ppm) total bergapten in consumer products (excluding wash-off products) applied to sun-exposed skin, as per IFRA guidelines.%
Sensitization risk Moderate

While generally considered safe for cosmetic use, high concentrations can lead to phototoxicity, primarily due to furanocoumarins like bergapten. Products containing this extract should be used with caution, particularly when applied to sun-exposed skin. Instances of phytophotodermatitis and contact dermatitis have been reported.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Ruta Graveolens Leaf Extract offers valuable antimicrobial and antioxidant benefits, particularly for blemish-prone skin, but requires careful formulation and usage due to its potential phototoxicity.

Related

Similar Ingredients

Finding similar ingredients…