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Moumoujus

RUBIA TINCTORUM ROOT.

Avoid CAS 84650-16-8 / SKIN CONDITIONING, SOOTHING, TONIC

Rubia tinctorum root is a botanical extract recognized for its anthraquinone pigments such as alizarin and purpurin. It has demonstrated antioxidant and antimicrobial activities, traditionally valued for its soothing and skin conditioning properties.

Summary

soothing skin conditioning tonic antioxidant anti-inflammatory antimicrobial

Science

Mechanism of Action

The primary mechanism of action for Rubia tinctorum root is attributed to its anthraquinone pigment content, including alizarin, purpurin, and rubiadin. These compounds contribute to its observed antioxidant capacity through radical scavenging and reducing abilities, exert anti-inflammatory effects, and provide antimicrobial action against a spectrum of pathogenic bacteria and fungi. Functionally, it acts as a skin conditioning agent, delivering soothing and tonic benefits.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Rubia tinctorum root extracts exhibit antioxidant activity, including DPPH radical scavenging, reducing ability (FRAP), and total antioxidant capacity (TAC).
  2. 02 Rubia tinctorum root extracts demonstrate antimicrobial activity against a wide range of pathogenic bacteria and fungi, with inhibition zones ranging from 10 to 15 mm.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 5
0 7 14

Stability

To optimize the uptake of active anthraquinone compounds and maintain vibrant coloration, formulations should be acidified to a pH range of 4.0-5.0. To preserve stability and prevent browning, processing temperatures should be maintained below 60-72°C (140-160°F).

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

Rubia tinctorum root contains lucidin, a compound definitively shown to be genotoxic both in vitro and in vivo. Long-term dietary studies in rats, at concentrations of 1% and 10% over 780 days, resulted in tumor development in the liver and kidneys, indicating significant carcinogenic potential. Mutagenic activity has also been observed in the Salmonella/microsome test. While acute and subacute toxicity tests in mice showed no immediate toxic effects at dietary concentrations up to 5% for 90 days, these short-term findings do not negate the established long-term genotoxic and carcinogenic risks associated with lucidin. Due to these severe safety concerns, particularly regarding genotoxicity and carcinogenicity, its use in cosmetic and skincare formulations is highly problematic.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its potential functional benefits, Rubia tinctorum root should be avoided in skincare due to significant genotoxic and carcinogenic risks identified from its constituent, lucidin, in both in vitro and in vivo studies.

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