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Moumoujus

ROSA DAVURICA CALLUS CULTURE EXTRACT.

Insufficient Data / ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

Rosa Davurica Callus Culture Extract utilizes the regenerative capacity of plant stem cells from the Davurian rose. This advanced extract is expected to provide potent antioxidant, anti-inflammatory, and protective benefits, addressing signs of aging and environmental stressors by harnessing the rich secondary metabolites inherent to callus cultures.

Summary

Antioxidant Anti-inflammatory Photoaging protection Collagen synthesis support ECM degradation inhibition Free radical scavenging Humectant Skin protecting Hair conditioning Skin regeneration Redness reduction Skin tone evening Vitality enhancement

Science

Mechanism of Action

This extract is anticipated to function similarly to Rosa davurica leaf and root extracts, demonstrating significant antioxidant, antiviral, and anti-inflammatory activities. It is hypothesized to inhibit skin photoaging by modulating key signaling pathways, including MAPK/AP-1, NF-κB, and Nrf2/HO-1, within UVB-irradiated human skin keratinocytes. Its action includes efficient scavenging of free radicals, dose-dependent reduction of reactive oxygen species (ROS) generation, and a decrease in UVB-induced matrix metalloproteinase-1 (MMP-1) expression, thereby preventing extracellular matrix (ECM) degradation. The extract may also enhance Nrf2/HO-1 signaling to bolster oxidative defense and activate transforming growth factor-beta (TGF-β) signaling to promote procollagen type I synthesis. Additionally, it could suppress inflammatory responses induced by *Propionibacterium acnes*.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has cited insufficient data for 'Rosa Centifolia Callus Culture Extract' (a related species) to determine its safety under cosmetic use conditions, requesting further information on manufacturing, composition, impurities, dermal toxicity, irritation, and sensitization. No specific safety assessments for 'ROSA DAVURICA CALLUS CULTURE EXTRACT' by CIR, SCCS, or FDA were identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

With compelling mechanistic data extrapolated from the parent plant and related callus extracts, this ingredient shows strong potential for anti-aging and skin protection, though specific clinical efficacy for the callus culture extract requires further dedicated investigation.

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