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Moumoujus

RICE SH-POLYPEPTIDE-1.

Questionable / HUMECTANT, OPACIFYING, SKIN CONDITIONING

RICE SH-POLYPEPTIDE-1 is a recombinant human peptide derived from transgenic rice, acting as an analog to Basic Fibroblast Growth Factor (bFGF). It is designed to stimulate cellular proliferation, contributing to enhanced skin elasticity and overall skin repair mechanisms.

Summary

Cell-Signaling Ingredient Skin-Conditioning Collagen Booster Elastin Enhancer Wound Healing Hydration Support

Science

Mechanism of Action

This ingredient functions as a growth factor peptide, stimulating the proliferation of fibroblasts, which are crucial for producing collagen and elastin, thereby improving skin elasticity and reducing wrinkles. It also regulates molecular factors essential for blood vessel development, controls epidermal cell propagation, migration, and differentiation, and enhances blood circulation. Furthermore, it promotes melanocyte migration for re-pigmentation, and synergistically with EGF and IGF-1, boosts hyaluronic acid synthesis for improved hydration. It supports scarless wound healing, strengthens the skin barrier, reduces inflammation, and increases the production of extracellular matrix components like collagen, elastin, and glycosaminoglycans.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Independent research on rice sh-oligopeptide-1 is notably scarce, making comprehensive evaluation challenging, with cosmetic supplier studies also being difficult to access.
  2. 02 Some scientific literature indicates that preclinical bioactivity for sh-oligopeptide-1 has not been definitively proven, questioning the scientific basis of some clinical claims.
  3. 03 Conversely, several clinical trials have suggested efficacy for sh-Oligopeptide-1 (Recombinant EGF) in specific applications, such as wound healing in diabetic patients post-laser treatment and in the management of Senile purpura.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to indicate that RICE SH-POLYPEPTIDE-1 is commonly 'dusted' or used at ineffective concentrations. However, due to limited independent research, assessing its typical usage patterns is difficult.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Rice protein peptide generally exhibits robust stability, maintaining its composition and function even when exposed to heat.

Synergies

  • Interacts with EGF and IGF-1 to amplify hyaluronic acid production.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While related ingredients like 'Hydrolyzed Rice Protein' have been deemed safe by CIR (2006), RICE SH-POLYPEPTIDE-1 itself has not undergone a dedicated CIR review. As a growth factor, it presents a potential for tumorigenesis if overexpression or dysregulation occurs, given that EGF signaling pathways are implicated in many tumor cells. Long-term risks associated with sh-EGF (sh-oligopeptide-1), a related authorized cosmetic ingredient, remain unknown, suggesting a cautious approach to its use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Due to a significant lack of independent research, conflicting efficacy claims, an unreviewed CIR status, and potential concerns regarding tumorigenesis as a growth factor, the inclusion of RICE SH-POLYPEPTIDE-1 warrants extreme caution.

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