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Moumoujus

RICE OLIGOPEPTIDE-91 SH-POLYPEPTIDE-1.

Insufficient Data / HUMECTANT, SKIN CONDITIONING

RICE OLIGOPEPTIDE-91 SH-POLYPEPTIDE-1 is a synthetically engineered peptide, derived from rice sources, designed to emulate the activity of specific growth factors within the skin. Its intended function is to promote anti-aging and rejuvenating effects by supporting protein synthesis and acting as a skin conditioning humectant.

Summary

Humectant Skin Conditioning

Science

Mechanism of Action

This synthetic peptide operates by mimicking the effects of sh-Oligopeptide-1, also known as Epidermal Growth Factor (EGF), a naturally occurring protein crucial for skin health. As a peptide, it theoretically encourages the skin's natural production of vital proteins like collagen and elastin. Beyond this, its mimetic action aims to stimulate skin repair mechanisms, enhance self-regeneration, promote new blood vessel formation, and support the proliferation of key skin cells such as keratinocytes, endothelial cells, and fibroblasts. This multifaceted approach is proposed to improve skin barrier function, mitigate inflammatory responses, reduce scar visibility, and deliver sustained moisturization.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Independent clinical research and studies specifically on 'RICE OLIGOPEPTIDE-91 SH-POLYPEPTIDE-1' are notably absent, making it challenging to definitively assess its direct effects in cosmetic applications.
  2. 02 Studies pertaining to sh-oligopeptide-1 (EGF), which this ingredient is designed to mimic, have been cited as lacking scientific basis, with preclinical bioactivity remaining unproven in certain contexts. Some cosmetic industry evaluations have even referred to sh-oligopeptide-1 as an inactive ingredient for topical use, despite favorable outcomes reported in medical trials that may not adhere to rigorous scientific standards.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding the dusting potential of this ingredient is not available in the provided data.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific stability details, including optimal pH range and notes on long-term stability, are not provided.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Personal Care Products Council classifies 'rice sh-oligopeptide-1' as a skin-conditioning agent. While sh-EGF (sh-oligopeptide-1) is broadly authorized for cosmetic use, its long-term safety, particularly in the context of topical applications, remains largely unknown. A significant concern with growth factors or their mimetics, such as this ingredient, is the potential for tumorigenesis (tumor formation) if overexpression or dysregulation occurs, given that EGF signaling is frequently observed in tumor cells. Therefore, any product containing an EGF-mimetic warrants careful consideration and cautious use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While conceptually designed to offer significant skin benefits by mimicking growth factors, the critical absence of robust, independent clinical studies to validate its efficacy and the notable safety concerns regarding potential tumorigenesis render this ingredient's role in precision skincare highly uncertain and warrant significant caution.

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