Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RIBOFLAVIN TETRAACETATE.

Valuable CAS 752-13-6 / SKIN CONDITIONING

Riboflavin Tetraacetate is a stabilized, oil-soluble derivative of Vitamin B2, engineered for enhanced stability and targeted action. It functions as a photosensitizer, leveraging light activation to address specific skin concerns, particularly mild to moderate acne vulgaris.

Summary

Photosensitizer Skin conditioning Antioxidant (indirect) Acne treatment

Science

Mechanism of Action

This acetylated derivative of riboflavin exhibits improved stability and enhanced oil solubility compared to its parent compound. Upon exposure to appropriate light wavelengths, Riboflavin Tetraacetate acts as a photosensitizer, generating reactive oxygen species (ROS). These ROS can neutralize pathogens and induce therapeutic effects in skin cells, making it a potential treatment for acne and microbial infections. Once absorbed and metabolized within the body, it releases free riboflavin, which is vital for cellular energy production and contributes to the skin's antioxidant defense by participating in redox reactions.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data available to indicate that Riboflavin Tetraacetate is commonly 'dusted' or used at ineffective percentages in formulations.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Riboflavin Tetraacetate is susceptible to hydrolysis in aqueous environments, reverting to riboflavin and acetic acid. This necessitates its integration into anhydrous or emulsion systems, potentially requiring careful pH control to maintain its stability and integrity. As a photosensitizer, its activation is contingent on light exposure, thus light-protective packaging (e.g., opaque containers) is essential if spontaneous light activation is not intended prior to application.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

There is no specific safety assessment available from the Cosmetic Ingredient Review (CIR) panel or the Scientific Committee on Consumer Safety (SCCS) for Riboflavin Tetraacetate. While its parent compound, Riboflavin (Vitamin B2), is permanently listed by the FDA as exempt from certification for food use, an explicit FDA cosmetic status or approval for Riboflavin Tetraacetate itself has not been specified. Cosmetic ingredients, apart from color additives, do not generally require pre-market FDA approval.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Riboflavin Tetraacetate is a valuable photosensitizing ingredient demonstrating comparable efficacy to established acne therapies with a notably more favorable side effect profile, positioning it as a promising candidate for targeted skin treatments, particularly for acne, despite its specific formulation requirements.

Related

Similar Ingredients

Finding similar ingredients…