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Moumoujus

RHYNCHOSIA NULUBILIS SEED EXTRACT.

Insufficient Data / ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Rhynchosia Nulubilis Seed Extract, derived from the black bean, is a botanical ingredient rich in isoflavones, saponins, and other beneficial compounds. It exhibits multifaceted actions, including potent antioxidant and anti-inflammatory properties, alongside a notable ability to promote melanogenesis. This extract also shows preliminary indications for supporting hair growth.

Summary

Antioxidant Skin-Conditioning Agent Melanogenesis Promoter Anti-inflammatory Hair Growth Promoter

Science

Mechanism of Action

This ingredient operates through several mechanisms attributable to its diverse functional components, such as isoflavones (including genistein, daidzein, and glycitein), saponins, anthocyanins, tocopherol, and phytic acid. Its antioxidant capacity stems from isoflavones, which effectively reduce reactive oxygen species (ROS) levels. The extract is recognized for promoting melanogenesis by significantly increasing melanin content and intracellular tyrosinase activity. Furthermore, it has been observed to stimulate human dermal papilla cell (hDPC) proliferation and enhance local blood vessel expansion, suggesting a potential role in facilitating hair growth. A closely related species, Rhynchosia volubilis, has also demonstrated promotion of cell survival via the cAMP-PKA/ERK-CREB pathway.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An ethanol extract of Rhynchosia nulubilis bean significantly increased melanin content by 30.4% and intracellular tyrosinase activity by 18.4% in melan-a cells, demonstrating melanogenesis-promoting effects.
  2. 02 Germinated Rhynchosia nulubilis, fermented with Lactobacillus pentosus SC65, displayed anti-inflammatory effects against delayed-type hypersensitivity in mice. (Note: This study involved oral administration).
  3. 03 An ethanol extract of Rhynchosia volubilis (a closely related species) significantly increased HeLa cell viability by 1.2-fold, promoting cell survival via the cAMP-PKA/ERK-CREB pathway. (Note: This study used a related species).

Transparency

Dusting Analysis

Not commonly dusted

No available data suggests that Rhynchosia Nulubilis Seed Extract is commonly used as a 'dusting' ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Formal safety assessments by authoritative bodies such as CIR, SCCS, or FDA specifically for Rhynchosia Nulubilis Seed Extract are not available. Dermal toxicity data for this ingredient remains undetermined. Paula's Choice indicates that it has not yet rated this ingredient due to a lack of comprehensive reviewed research, highlighting a need for further safety evaluation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Rhynchosia Nulubilis Seed Extract demonstrates promising in vitro antioxidant, anti-inflammatory, melanogenesis-promoting, and hair growth potential, a lack of comprehensive human topical efficacy and safety data renders it currently unrated for definitive cosmetic application.

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