Science
Mechanism of Action
This root powder, particularly its rhinacanthin-rich extracts, exerts broad-spectrum antimicrobial activity against various bacteria including S. mutans, S. epidermidis, P. acnes, and S. aureus, alongside potent fungicidal effects by targeting fungal cell walls. Its antioxidant and anti-inflammatory benefits are attributed to water-soluble phenolic compounds like tannins. Tannins may also interact with skin proteins, potentially refining pore appearance and influencing sebum regulation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A topical gel containing 0.1% rhinacanthin C from root extract demonstrated in vitro antifungal activity against dermatophytes and showed no genotoxicity, skin corrosion, or dermal irritation in animal models or human patch tests.
- 02 A facial toner formulated with 0.20% w/w Rhinacanthus nasutus extract was found physically stable and safe for human volunteers (MII score of 0.00), although it did not show superior sebum control compared to a placebo.
- 03 Root extract (250 mg/mL, containing estimated 2.5% rhinacanthin-C) exhibited significant in vitro antifungal efficacy against Cryptococcus neoformans, reducing melanin production and altering cell structure.
Transparency
Dusting Analysis
No data suggests this ingredient is commonly used in ineffective concentrations for marketing purposes.
The Formula
Formulation
Stability
Extracts are generally stable when protected from light and stored at 4±2°C or 30±2°C for up to 4 months. However, they degrade with light exposure after 1 week and at accelerated conditions (45°C, 75% relative humidity) after 8 weeks. Rhinacanthins are more stable at pH 5.5 compared to higher pH levels (7.0-8.0).
Synergies
- Extraction using 25% glycerol in ethanol can enhance rhinacanthin-C solubility and stability, compatible with topical formulations.
Conflicts
- Light exposure (causes instability after 1 week)
- Higher pH environments (e.g., pH 7.0 and 8.0 for rhinacanthins)
Safety
Safety Profile
Topical preparations of Rhinacanthus nasutus root extract (0.1% rhinacanthin C in gel, 0.20% w/w extract in toner) have demonstrated a low sensitization risk, being non-genotoxic, non-skin corrosive, and causing no dermal irritation or adverse skin reactions in human volunteer tests. Extract concentrations up to 0.1% w/w were safe for human fibroblasts, exhibiting good cell survival.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rhinacanthus Nasutus Root Powder is a valuable ingredient, particularly for problematic and sensitive skin, offering potent antimicrobial, antioxidant, and anti-inflammatory benefits with a robust safety profile for topical application in concentrations up to 0.20% w/w of its extract.
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References
Sources