Science
Mechanism of Action
This ingredient operates via several distinct mechanisms to promote skin health. It protects cellular integrity by shielding skin cells from INF-γ and TNF-α induced apoptosis, likely through its antioxidant capabilities. It actively scavenges free radicals and modulates nitric oxide activity, further mitigating oxidative stress. Key active compounds, including tannins, rhinacanthins (naphthoquinones), polyphenols, naphthoquinone esters, phenolic compounds, steroids, quinones, and terpenoids, collectively contribute to its broad spectrum of benefits. Tannins specifically can bind to proteins within skin pores, potentially reducing sebum secretion and refining pore size. Its antimicrobial action targets common skin flora such as *S. epidermidis* and *P. acnes*, while anti-inflammatory effects are mediated by inhibiting TNFα release and preventing NF-κB activation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies utilizing *R. nasutus* leaf extracts demonstrated significant biological activities. A leaf extract at 25 mg/mL effectively inhibited the growth of various test microorganisms. A prepared soap with a similar concentration also inhibited test microorganisms, showing inhibition zones ranging from 0.7±0.1 mm to 1.3±0.1 mm.
- 02 Further in vitro investigations revealed antifungal activity of leaf, root, or combined extracts against *Saccharomyces cerevisiae* and *Cryptococcus neoformans* at concentrations ranging from 4 to 16 mg/mL. The strongest antifungal effect was observed at 8 mg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Tannins, which are water-soluble phenolic compounds, are present in the leaves. Glycerol has been shown to enhance the solubility and stability of rhinacanthin-C, a principal antifungal compound, when used in an ethanol solvent for extraction. Formulated toners containing *R. nasutus* extract have demonstrated good physical stability.
Synergies
- Glycerol (enhances solubility and stability of rhinacanthin-C)
Safety
Safety Profile
A topical preparation of *R. nasutus* root extract containing 0.1% rhinacanthin C did not cause mutations in bacteria, nor did it irritate or corrode animal skin. It also produced no skin reactions in healthy human volunteers during a single patch test, indicating safety for such applications. An *R. nasutus* extract (RNE) was found safe in HDFa cytotoxicity tests at concentrations between 0.001 and 1.0 mg/mL, with cell survival rates of 78.37%–94.00%. A toner formulated with RNE showed good physical stability and safety in human volunteers with an MII score of 0.00, indicating no irritation. However, long-term safety of its tea infusions for consumption has not been tested.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rhinacanthus Nasutus Leaf Powder is a valuable botanical ingredient offering diverse benefits for skin, including potent antimicrobial, antioxidant, and anti-inflammatory effects, alongside sebum regulation and pore refinement, with a low topical sensitization risk.
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