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Moumoujus

RHINACANTHUS NASUTUS EXTRACT.

Valuable / SKIN CONDITIONING

Rhinacanthus Nasutus Extract is a multi-functional botanical ingredient offering potent antioxidant, anti-inflammatory, and antimicrobial benefits. Derived from a plant traditionally used for various skin ailments, it supports overall skin health by protecting cells, calming irritation, and combating problematic microorganisms.

Summary

Antioxidant Anti-inflammatory Antimicrobial Antifungal Astringent Anti-allergy

Science

Mechanism of Action

This extract exhibits robust antioxidant capabilities by neutralizing superoxide radicals and shielding skin cells from pro-inflammatory cytokine-induced apoptosis (INF-γ and TNF-α). Its anti-inflammatory action stems from inhibiting TNFα release and preventing NF-κB activation, with specific rhinacanthins (C and D) contributing to this effect. It also demonstrates broad-spectrum antimicrobial and antifungal activity, targeting fungal cell walls and inhibiting bacterial strains such as S. mutans, S. epidermidis, P. acnes, and S. aureus. Naphthoquinone derivatives, including rhinacanthins C, D, and N, confer anti-allergic potential by suppressing antigen-induced beta-hexosaminidase, TNF-alpha, and IL-4 release. Additionally, the presence of tannins provides astringent properties.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An 8 mg/mL concentration demonstrated high efficacy in suppressing yeast growth (Saccharomyces cerevisiae and Cryptococcus neoformans) in vitro, highlighting its antifungal potential.
  2. 02 A topical root extract gel containing 0.1% rhinacanthin C was found to be non-genotoxic, non-skin corrosive, and non-irritating in animal models. A single patch test on human volunteers also showed no dermal irritation, confirming its safety for topical application.
  3. 03 In human dermal fibroblast adult (HDFa) cytotoxicity tests, concentrations ranging from 0.001 to 1.0 mg/mL resulted in cell survival rates between 78.37% and 94.00%, indicating good safety at these levels.
  4. 04 A toner formulation incorporating Rhinacanthus nasutus extract did not achieve a significant reduction in sebum compared to a placebo, suggesting it is not effective for sebum control.

Transparency

Dusting Analysis

Not commonly dusted

No specific data suggests this ingredient is commonly 'dusted' at ineffective concentrations. Its range of benefits implies a functional purpose.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract exhibits instability when exposed to light, showing degradation after 1 week. Under accelerated conditions (45°C with 75% relative humidity), it was unstable after 8 weeks. Aqueous methanolic solutions were found to be unstable across tested pH values (5.5, 7.0, 8.0), although stability was comparatively better at pH 5.5. It is best soluble in water, alcohol, acetone, and DMSO, but insoluble in ethyl acetate, chloroform, and hexane.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.1% rhinacanthin C%
Sensitization risk Low

A topical gel containing 0.1% rhinacanthin C was confirmed non-genotoxic, non-skin corrosive, and non-irritating in animal studies and human patch tests. In vitro, concentrations up to 1.0 mg/mL showed high cell survival. Regulatory bodies such as CIR, SCCS, or FDA have not evaluated its safety.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rhinacanthus Nasutus Extract is a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and antimicrobial properties with a low irritancy profile, despite its challenging stability characteristics and unproven sebum control.

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