Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40.

Avoid / HAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING

RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 is a synthetic 184-amino acid fusion peptide, engineered via E. coli fermentation. This sophisticated signaling molecule is designed to activate the skin's intrinsic repair mechanisms, particularly targeting the slower regeneration observed in mature skin. It functions to enhance skin health, strengthen its structure, and visibly reduce the appearance of wrinkles.

Summary

Skin Conditioning Skin Protecting

Science

Mechanism of Action

This complex peptide acts as both a skin conditioning and protecting agent. By mimicking the skin's natural repair processes, it stimulates the proliferation and growth of dermal cells, particularly fibroblasts, which are critical for boosting endogenous collagen and elastin production. A key component, sh-Polypeptide-11 (a recombinant acidic Fibroblast Growth Factor analog), drives this cellular growth and structural reinforcement. Additionally, it exhibits potent antioxidant capabilities, effectively reducing free radicals and inhibiting cellular aging.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Due to the substantial molecular size of its sh-Polypeptide-11 component, encapsulation in carrier systems like lipid spheres or liposomes may be necessary to facilitate optimal penetration through the stratum corneum and ensure effective action in deeper skin layers. For its Hexapeptide-11 component, it is advisable to incorporate into the aqueous phase of formulations at temperatures maintained below 40°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 is classified as a 'PROHIBITED INGREDIENT' by the EU under restriction II/416. There is no specific safety assessment by the Cosmetic Ingredient Review (CIR) or the FDA for this exact ingredient. While a related ingredient, Sr-(Hexapeptide-40 Oligopeptide-91 Clostridium Botulinum Polypeptide-1), is generally considered safe for topical application, data for pregnant or breastfeeding individuals is lacking, recommending professional healthcare consultation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Avoid

Despite its promising mechanistic profile for advanced skin regeneration and protection, RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40 is strictly prohibited for cosmetic use in the EU, rendering its inclusion in formulations unfeasible.

Related

Similar Ingredients

Finding similar ingredients…